Analysis of Serum Advanced Glycation Endproducts Reveals Methylglyoxal-Derived Advanced Glycation MG-H1 Free Adduct Is a Risk Marker in Non-Diabetic and Diabetic Chronic Kidney Disease
المؤلف | Rabbani, Naila |
المؤلف | Adaikalakoteswari, Antonysunil |
المؤلف | Larkin, James R. |
المؤلف | Panagiotopoulos, Sianna |
المؤلف | MacIsaac, Richard J. |
المؤلف | Yue, Dennis K. |
المؤلف | Fulcher, Gregory R. |
المؤلف | Roberts, Matthew A. |
المؤلف | Thomas, Merlin |
المؤلف | Ekinci, Elif |
المؤلف | Thornalley, Paul J. |
تاريخ الإتاحة | 2023-10-11T10:41:42Z |
تاريخ النشر | 2022-12-21 |
اسم المنشور | International Journal of Molecular Sciences |
المعرّف | http://dx.doi.org/10.3390/ijms24010152 |
الاقتباس | Rabbani, N., Adaikalakoteswari, A., Larkin, J. R., Panagiotopoulos, S., MacIsaac, R. J., Yue, D. K., ... & Thornalley, P. J. (2022). Analysis of serum advanced glycation endproducts reveals methylglyoxal-derived advanced glycation MG-H1 free adduct is a risk marker in non-diabetic and diabetic chronic kidney disease. International Journal of Molecular Sciences, 24(1), 152. |
الرقم المعياري الدولي للكتاب | 1661-6596 |
الملخص | Accumulation of advanced glycation endproducts (AGEs) is linked to decline in renal function, particularly in patients with diabetes. Major forms of AGEs in serum are protein-bound AGEs and AGE free adducts. In this study, we assessed levels of AGEs in subjects with and without diabetes, with normal renal function and stages 2 to 4 chronic kidney disease (CKD), to identify which AGE has the greatest progressive change with decline in renal function and change in diabetes. We performed a cross-sectional study of patients with stages 2–4 CKD, with and without diabetes, and healthy controls (n = 135). Nine protein-bound and free adduct AGEs were quantified in serum. Most protein-bound AGEs increased moderately through stages 2–4 CKD whereas AGE free adducts increased markedly. Methylglyoxal-derived hydroimidazolone MG-H1 free adduct was the AGE most responsive to CKD status, increasing 8-fold and 30-fold in stage 4 CKD in patients without and with diabetes, respectively. MG-H1 Glomerular filtration flux was increased 5-fold in diabetes, likely reflecting increased methylglyoxal glycation status. We conclude that serum MG-H1 free adduct concentration was strongly related to stage of CKD and increased in diabetes status. Serum MG-H1 free adduct is a candidate AGE risk marker of non-diabetic and diabetic CKD. |
راعي المشروع | This research was funded by a research grant from: - National Health and Medical Research Council (NHMRC) # No. 310632 - Austin Hospital Medical Research Foundation Grant (2003) - Qatar Foundation, grant number QB14 - NR by Qatar University, grant number QU ERG-CMED-2020-1 - Sir Edward Weary Dunlop Medical Research Foundation, National Health and Medical Research Council (NHMRC), Medical Research Future Fund and MTP Connect, Australia. |
اللغة | en |
الناشر | Multidisciplinary Digital Publishing Institute (MDPI) |
الموضوع | chronic kidney disease diabetes estimated glomerular filtration rate glycation methylglyoxal |
النوع | Article |
رقم العدد | 1 |
رقم المجلد | 24 |
ESSN | 1422-0067 |
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