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AuthorSotgia, Salvatore
AuthorMangoni, Arduino A.
AuthorForteschi, Mauro
AuthorMurphy, Rhys B.
AuthorElliot, David
AuthorSotgiu, Elisabetta
AuthorPintus, Gianfranco
AuthorCarru, Ciriaco
AuthorZinellu, Angelo
Available date2016-10-12T10:27:20Z
Publication Date2016-09-28
Publication NameMoleculesen_US
Identifierhttp://dx.doi.org/10.3390/molecules21101298
CitationSotgia, S.; Mangoni, A.A.; Forteschi, M.; Murphy, R.B.; Elliot, D.; Sotgiu, E.; Pintus, G.; Carru, C.; Zinellu, A. Identification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens. Molecules 2016, 21, 1298.
URIhttp://hdl.handle.net/10576/4876
AbstractA capillary electrophoresis coupled to tandem mass spectrometry (CE–MS/MS) has been used to make a qualitative determination of hercynine—the main precursor of l-ergothioneine biosynthesis—in some key human biological specimens, such as urine, whole blood, plasma, and saliva. From semiquantitative analysis results, the highest concentrations of hercynine were detected in saliva and whole blood, whereas much lower concentrations were measured in urine and plasma. Whole blood was the biological matrix with the highest concentration of l-ergothioneine followed by plasma, saliva, and urine. The antioxidant effects attributed to l-ergothioneine, along with its peculiar antioxidant mechanism, offer a possible explanation for the presence of the hercynine, as well as its concentration, in the considered biological matrices.
Sponsor"Fondazione Banco di Sardegna”, Sassari, Italy, and by the “Ministero dell’Università e della Ricerca”, Italy
Languageen
PublisherMDPI AG
Subjectaminothione
Subjectcapillary electrophoresis
Subjectmass spectrometry
Subjectquaternary ammonium
Subjectdismutation
TitleIdentification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens
TypeArticle
Issue Number10
Volume Number21
dc.identifier.essn 1420-3049


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