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المؤلفPurayil, Nishan Kunnummal
المؤلفNaushad, Vamanjore A.
المؤلفChandra, Prem
المؤلفJoseph, Prakash
المؤلفKhalil, Zahida
المؤلفZahid, Muhammad
المؤلفWilson, Godwin
المؤلفKayakkool, Muhammed Kunhi
المؤلفAyari, Basma
المؤلفChalihadan, Sajid
المؤلفElmagboul, Emad Bashier I.
المؤلفDoiphode, Sanjay H.
تاريخ الإتاحة2023-10-24T08:17:14Z
تاريخ النشر2023
اسم المنشورInfection and Drug Resistance
المصدرScopus
الرقم المعياري الدولي للكتاب11786973
معرّف المصادر الموحدhttp://dx.doi.org/10.2147/IDR.S415096
معرّف المصادر الموحدhttp://hdl.handle.net/10576/48814
الملخصPurpose: To study the association between proton pump inhibitor (PPI) use and the risk of urinary tract infection (UTI) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL). Patients and Methods: A retrospective cross-sectional study was conducted between October 2018 and September 2019. Adults with ESBL-UTIs were compared to adults with UTIs caused by gram-negative bacteria (GNB) and those with UTIs caused by miscellaneous organisms. The association between ESBL infection and PPI use was assessed. Results: A total of 117 of 277 ESBL cases, 229 of 679 non-ESBL GNB controls, and 57 of 144 non-ESBL miscellaneous controls were exposed to PPIs within 3 months prior to admission. The univariate analysis indicated unadjusted odds ratio for PPI exposure with ESBL infection versus the GNB controls was 1.43 (95% CI 1.07-1.90, P = 0.015) while the odds ratio for PPI exposure with ESBL infection versus miscellaneous organisms was 1.10 (95% CI 0.73-1.67, P = 0.633) indicating positive association (PPI exposure increases risk of ESBL infection). Multivariate analysis revealed a positive association between ESBL infection and PPI use versus the GNB controls with an odds ratio of 1.74 (95% CI 0.91-3.31). While Esomeprazole was positively associated with ESBL infection, particularly compared with the miscellaneous group (adjusted OR 1.35, 95% CI 0.47-3.88), Lansoprazole was inversely associated (adjusted OR 0.48, 95% CI 0.18-1.24 and adjusted OR 0.40, 95% CI 0.11-1.41 for ESBL versus GNB controls and ESBL versus miscellaneous organisms, respectively). Conclusion: Exposure to PPIs in the preceding 3 months showed an association with increased risk of ESBL-UTI. While Esomeprazole showed a positive association, Lansoprazole had an inverse association for ESBL-UTI. Restricting the use of PPIs may be beneficial in the fight against antimicrobial resistance.
اللغةen
الناشرDove Medical Press Ltd
الموضوعESBL
Extended-spectrum beta-lactamase
PPI
Proton pump inhibitor
Urinary tract infections
العنوانAssociation between proton pump inhibitor use and extended-spectrum beta-lactamase urinary tract infection in adults: A retrospective study
النوعArticle
الصفحات4251-4258
رقم المجلد16
dc.accessType Abstract Only


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