Show simple item record

AuthorPurayil, Nishan Kunnummal
AuthorNaushad, Vamanjore A.
AuthorChandra, Prem
AuthorJoseph, Prakash
AuthorKhalil, Zahida
AuthorZahid, Muhammad
AuthorWilson, Godwin
AuthorKayakkool, Muhammed Kunhi
AuthorAyari, Basma
AuthorChalihadan, Sajid
AuthorElmagboul, Emad Bashier I.
AuthorDoiphode, Sanjay H.
Available date2023-10-24T08:17:14Z
Publication Date2023
Publication NameInfection and Drug Resistance
ResourceScopus
ISSN11786973
URIhttp://dx.doi.org/10.2147/IDR.S415096
URIhttp://hdl.handle.net/10576/48814
AbstractPurpose: To study the association between proton pump inhibitor (PPI) use and the risk of urinary tract infection (UTI) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL). Patients and Methods: A retrospective cross-sectional study was conducted between October 2018 and September 2019. Adults with ESBL-UTIs were compared to adults with UTIs caused by gram-negative bacteria (GNB) and those with UTIs caused by miscellaneous organisms. The association between ESBL infection and PPI use was assessed. Results: A total of 117 of 277 ESBL cases, 229 of 679 non-ESBL GNB controls, and 57 of 144 non-ESBL miscellaneous controls were exposed to PPIs within 3 months prior to admission. The univariate analysis indicated unadjusted odds ratio for PPI exposure with ESBL infection versus the GNB controls was 1.43 (95% CI 1.07-1.90, P = 0.015) while the odds ratio for PPI exposure with ESBL infection versus miscellaneous organisms was 1.10 (95% CI 0.73-1.67, P = 0.633) indicating positive association (PPI exposure increases risk of ESBL infection). Multivariate analysis revealed a positive association between ESBL infection and PPI use versus the GNB controls with an odds ratio of 1.74 (95% CI 0.91-3.31). While Esomeprazole was positively associated with ESBL infection, particularly compared with the miscellaneous group (adjusted OR 1.35, 95% CI 0.47-3.88), Lansoprazole was inversely associated (adjusted OR 0.48, 95% CI 0.18-1.24 and adjusted OR 0.40, 95% CI 0.11-1.41 for ESBL versus GNB controls and ESBL versus miscellaneous organisms, respectively). Conclusion: Exposure to PPIs in the preceding 3 months showed an association with increased risk of ESBL-UTI. While Esomeprazole showed a positive association, Lansoprazole had an inverse association for ESBL-UTI. Restricting the use of PPIs may be beneficial in the fight against antimicrobial resistance.
Languageen
PublisherDove Medical Press Ltd
SubjectESBL
Extended-spectrum beta-lactamase
PPI
Proton pump inhibitor
Urinary tract infections
TitleAssociation between proton pump inhibitor use and extended-spectrum beta-lactamase urinary tract infection in adults: A retrospective study
TypeArticle
Pagination4251-4258
Volume Number16
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record