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المؤلفAl-Omari, Mothana K.
المؤلفElaarag, Mai
المؤلفAl-Zoubi, Raed M.
المؤلفAl-Qudimat, Ahmad R.
المؤلفZarour, Ayman A.
المؤلفAl-Hurani, Enas A.
المؤلفFares, Zainab E.
المؤلفAlkharraz, Leena M.
المؤلفShkoor, Mohanad
المؤلفBani-Yaseen, Abdulilah D.
المؤلفAboumarzouk, Omar M.
المؤلفYassin, Aksam
المؤلفAl-Ansari, Abdulla A.
تاريخ الإتاحة2023-11-05T06:14:30Z
تاريخ النشر2023
اسم المنشورJournal of Enzyme Inhibition and Medicinal Chemistry
المصدرScopus
الرقم المعياري الدولي للكتاب14756366
معرّف المصادر الموحدhttp://dx.doi.org/10.1080/14756366.2023.2220084
معرّف المصادر الموحدhttp://hdl.handle.net/10576/49017
الملخصBoronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can mimic certain types of antibodies to fight infections. They have been designed and developed into drugs, and this approach has emerged in the last 20 years. Five boronic acid drugs have been approved by the FDA and Health Canada, two of which are used to treat cancer, specifically multiple myeloma. The purpose of this review is to investigate boronic acid/ester derivatives as potential pharmaceutical agents as well as the mechanism of action. It will concentrate on six types of cancer: multiple myeloma, prostate cancer, breast cancer, lung cancer, cervical cancer, and colon cancer. Some newly developed boron-containing compounds have already demonstrated highly promising activities, but further investigation is required before final conclusions can be drawn.
راعي المشروعThe publication of this article was funded by the Qatar National Library. Open Access funding provided by the Qatar National Library.
اللغةen
الناشرTaylor and Francis Ltd.
الموضوعBoronic acid
cancer disease
drug
enzyme inhibitor
mechanism
العنوانOrganoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
النوعArticle Review
رقم العدد1
رقم المجلد38


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