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المؤلفParic, Ana
المؤلفKaran-Krizanac, Dragana
المؤلفSaric, Ivan
المؤلفVranic, Semir
تاريخ الإتاحة2023-11-12T06:16:01Z
تاريخ النشر2023-01-01
اسم المنشورCase Reports in Oncology
المعرّفhttp://dx.doi.org/10.1159/000533377
الاقتباسParic, A., Karan-Krizanac, D., Saric, I., & Vranic, S. (2023). A Chromosome 9p24. 1 Amplification in Colorectal Cancer with Metastases to the Kidney and Adrenal Gland: A Case Report. Case Reports in Oncology, 16(1), 797-804.‏
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85171549757&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/49157
الملخصColorectal cancer (CRC) is the third leading cause of mortality worldwide. The Food and Drug Administration recently designated pembrolizumab, an immune checkpoint inhibitor (ICI) against a programmed death-1 receptor, as a breakthrough drug for the treatment of patients with mCRC whose tumors have deficient mismatch-repair gene expression (as evidenced by microsatellite instability-high) and patients with solid tumors with a high tumor mutational burden with ≥10 mutations/megabase. We present a patient with metastatic CRC having renal and adrenal gland metastases. Comprehensive molecular profiling performed on a site of metastatic CRC in the kidney revealed multiple genomic alterations characteristic of CRC and rare chromosome 9p24.1 amplification, resulting in a co-amplification of the PDL1, PDL2, and JAK2 genes. Although this genomic alteration may predict the response to ICI, the lack of pembrolizumab prevented the patient from receiving targeted treatment and succumbing to the disease.
اللغةen
الناشرkarger
الموضوعAdrenal metastasis
Colorectal cancer
Immune checkpoint inhibitors
Molecular profiling
Programmed cell death ligand 1
Programmed cell death ligand 2
Renal metastasis
العنوانA Chromosome 9p24.1 Amplification in Colorectal Cancer with Metastases to the Kidney and Adrenal Gland: A Case Report
النوعArticle
الصفحات797-804
dc.accessType Abstract Only


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