Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report
| Author | Tomic, Kresimir |
| Author | Karan Krizanac, Dragana |
| Author | Skenderi, Faruk |
| Author | Krpina, Kristina |
| Author | Carapina Bilic, Andrea |
| Author | Galic, Kristina |
| Author | Gatalica, Zoran |
| Author | Vranic, Semir |
| Available date | 2023-11-14T06:55:23Z |
| Publication Date | 2023-01-01 |
| Publication Name | Respiratory Medicine Case Reports |
| Identifier | http://dx.doi.org/10.1016/j.rmcr.2023.101920 |
| Citation | Tomic, K., Krizanac, D. K., Skenderi, F., Krpina, K., Bilic, A. C., Galic, K., ... & Vranic, S. (2023). Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report. Respiratory Medicine Case Reports, 45, 101920. |
| Abstract | Small cell lung cancer (SCLC) is a highly aggressive malignancy with a poor outcome. We present the case of a 57-year-old male patient with extensive-stage (ES-SCLC) treated with chemotherapy and atezolizumab. A complete response was achieved with a long remission of ∼three years. Comprehensive genomic profiling (CGP) of the tumor revealed high tumor mutation burden (13 mutations/Mb) and mutations of TP53, RB1 and ERCC4 genes. This case study confirms that a complete response to chemoimmunotherapy may be achieved in the case of ES-SCLC. It further provides the additional value of CGP and predictive testing in the management of ES-SCLC. |
| Language | en |
| Publisher | Elsevier |
| Subject | Atezolizumab Genomic profiling Immunotherapy Lung cancer Small cell lung cancer |
| Type | Article |
| Volume Number | 45 |
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