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AuthorZiegler, Colleen
AuthorMir, Alain
AuthorAnandakrishnan, Sangeetha
AuthorMartin, Patrick
AuthorContreras, Elma
AuthorSlemons, Isaiah
AuthorWitkowski, Barbara
AuthorDeSilva, Chris
AuthorFarmer, Andrew
AuthorVranic, Semir
AuthorGatalica, Zoran
AuthorRichardson, David
AuthorDerkach, Dmitry N.
Available date2023-11-19T05:45:34Z
Publication Date2023
Publication NameMolecular Oncology
ResourceScopus
ISSN15747891
URIhttp://dx.doi.org/10.1002/1878-0261.13515
URIhttp://hdl.handle.net/10576/49425
AbstractThe role of the tumor microenvironment (TME) in immuno-oncology has driven demand for technologies that deliver in situ, or spatial, molecular information. Compartmentalized heterogeneity that traditional methods miss is becoming key to predicting both acquired drug resistance to targeted therapies and patient response to immunotherapy. Here, we describe a novel method for assay-agnostic spatial profiling and demonstrate its ability to detect immune microenvironment signatures in breast cancer patients that are unresolved by the immunohistochemical (IHC) assessment of programmed cell death ligand-1 (PD-L1) on immune cells, which represents the only FDA microenvironment-based companion diagnostic test that has been approved for triple-negative breast cancer (TNBC). Two distinct physiological states were found that are uncorrelated to tumor mutational burden (TMB), microsatellite instability (MSI), PD-L1 expression, and intrinsic cancer subtypes.
SponsorThis research was supported by the National Science Foundation SBIR program (Awards: 1647818 and 1758649). We thank our colleagues from Takara Bio, USA who provided support with custom assay development, as well as Caris Life Sciences who provided samples and clinical insights for this project.
Languageen
PublisherJohn Wiley and Sons Ltd
Subjectimmuno-oncology
spatial profiling
triple-negative breast cancer
tumor microenvironment
TitleAssay-agnostic spatial profiling detects tumor microenvironment signatures: new diagnostic insights for triple-negative breast cancer
TypeArticle
Pagination1953-1961
Issue Number10
Volume Number17
dc.accessType Open Access


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