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المؤلفHassan, Arij Fouzat
المؤلفKhalil, Ashraf
المؤلفAl Moustafa, Ala‐Eddin
تاريخ الإتاحة2023-11-19T05:45:37Z
تاريخ النشر2023
اسم المنشورJordan Journal of Pharmaceutical Sciences
المصدرScopus
الرقم المعياري الدولي للكتاب19957157
معرّف المصادر الموحدhttp://dx.doi.org/10.35516/jjps.v16i2.1528
معرّف المصادر الموحدhttp://hdl.handle.net/10576/49451
الملخصElaeagnus angustifolia (EA) is a traditional plant that has been used as an alternative medicine for centuries. EA roles as anti-cancer has been investigated against different types of cancer, however, its effect against human cancer has not been investigated yet. Therefore, we investigated the aqueous EA extract effect on colorectal cancer (CRC) cell lines (HCT-116 and LoVo) and examined its underlying mechanisms of action in vitro. Our results showed that EA inhibited cell proliferation and disturbed cell-cycle progression of both CRC cell lines comparing to the control. Moreover, EA extract significantly reduced colony formation in addition to migration and invasion ability of both CRC cell lines this is confirmed by significant upregulation of E-cadherin and Pan-cadherin as well as down regulation of Vimentin. Further, β-catenin/JNK signaling pathway was analyzed and we found that EA extract significantly blocked the activity of total and phosphorylated β-catenin and JNK1/2/3.
اللغةen
الناشرUniversity of Jordan,Deanship of Scientific Research
الموضوعElaeagnus Angustifolia Plant
Human Colorectal Cancer
β-catenin
colorectal cancer (CRC)
العنوانElaeagnus Angustifolia Plant Extract inhibits Epithelial- mesenchymal Transition in Human Colorectal Cancer via β-catenin/JNK signaling Pathways
النوعArticle
الصفحات471
رقم العدد2
رقم المجلد16
dc.accessType Open Access


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