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AuthorHassan, Arij Fouzat
AuthorKhalil, Ashraf
AuthorAl Moustafa, Ala‐Eddin
Available date2023-11-19T05:45:37Z
Publication Date2023
Publication NameJordan Journal of Pharmaceutical Sciences
ResourceScopus
ISSN19957157
URIhttp://dx.doi.org/10.35516/jjps.v16i2.1528
URIhttp://hdl.handle.net/10576/49451
AbstractElaeagnus angustifolia (EA) is a traditional plant that has been used as an alternative medicine for centuries. EA roles as anti-cancer has been investigated against different types of cancer, however, its effect against human cancer has not been investigated yet. Therefore, we investigated the aqueous EA extract effect on colorectal cancer (CRC) cell lines (HCT-116 and LoVo) and examined its underlying mechanisms of action in vitro. Our results showed that EA inhibited cell proliferation and disturbed cell-cycle progression of both CRC cell lines comparing to the control. Moreover, EA extract significantly reduced colony formation in addition to migration and invasion ability of both CRC cell lines this is confirmed by significant upregulation of E-cadherin and Pan-cadherin as well as down regulation of Vimentin. Further, β-catenin/JNK signaling pathway was analyzed and we found that EA extract significantly blocked the activity of total and phosphorylated β-catenin and JNK1/2/3.
Languageen
PublisherUniversity of Jordan,Deanship of Scientific Research
SubjectElaeagnus Angustifolia Plant
Human Colorectal Cancer
β-catenin
colorectal cancer (CRC)
TitleElaeagnus Angustifolia Plant Extract inhibits Epithelial- mesenchymal Transition in Human Colorectal Cancer via β-catenin/JNK signaling Pathways
TypeArticle
Pagination471
Issue Number2
Volume Number16
dc.accessType Open Access


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