Show simple item record

AuthorAl-Fahdawi, Mohamed Qasim
AuthorRasedee, Abdullah
AuthorAl-Qubaisi, Mothanna Sadiq
AuthorAlhassan, Fatah H.
AuthorRosli, Rozita
AuthorEl Zowalaty, Mohamed Ezzat
AuthorNaadja, Seif-Eddine
AuthorWebster, Thomas J.
AuthorTaufiq-Yap, Yun Hin
Available date2016-11-06T07:59:18Z
Publication Date2015-09-10
Publication NameInternational Journal of Nanomedicineen_US
Identifierhttps://doi.org/10.2147/IJN.S82586
CitationAl-Fahdawi MQ, Rasedee A, Al-Qubaisi MS, et al. Cytotoxicity and physicochemical characterization of iron–manganese-doped sulfated zirconia nanoparticles. International Journal of Nanomedicine. 2015;10:5739-5750.
ISSN1176-9114
URIhttp://hdl.handle.net/10576/4971
AbstractIron–manganese-doped sulfated zirconia nanoparticles with both Lewis and Brønsted acidic sites were prepared by a hydrothermal impregnation method followed by calcination at 650°C for 5 hours, and their cytotoxicity properties against cancer cell lines were determined. The characterization was carried out using X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, Brauner–Emmett–Teller (BET) surface area measurements, X-ray fluorescence, X-ray photoelectron spectroscopy, zeta size potential, and transmission electron microscopy (TEM). The cytotoxicity of iron–manganese-doped sulfated zirconia nanoparticles was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays against three human cancer cell lines (breast cancer MDA-MB231 cells, colon carcinoma HT29 cells, and hepatocellular carcinoma HepG2 cells) and two normal human cell lines (normal hepatocyte Chang cells and normal human umbilical vein endothelial cells [HUVECs]). The results suggest for the first time that iron–manganese-doped sulfated zirconia nanoparticles are cytotoxic to MDA-MB231 and HepG2 cancer cells but have less toxicity to HT29 and normal cells at concentrations from 7.8 µg/mL to 500 µg/mL. The morphology of the treated cells was also studied, and the results supported those from the cytotoxicity study in that the nanoparticle-treated HepG2 and MDA-MB231 cells had more dramatic changes in cell morphology than the HT29 cells. In this manner, this study provides the first evidence that iron–manganese-doped sulfated zirconia nanoparticles should be further studied for a wide range of cancer applications without detrimental effects on healthy cell functions.
Languageen
PublisherDove Press
SubjectHT29 cells
SubjectLewis and Brønsted acidic sites
Subjectanticancer applications
Subjectnanopartices
Subjecttransition metal oxide
TitleCytotoxicity and physicochemical characterization of iron–manganese-doped sulfated zirconia nanoparticles
TypeArticle
Pagination5739-5750
Issue Number1
Volume Number10
ESSN1178-2013


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record