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AuthorAl Moustafa, Ala-Eddin
Available date2016-11-09T06:42:12Z
Publication Date2015-07-15
Publication NameCell Adhesion & Migrationen_US
Identifierhttp://dx.doi.org/10.1080/19336918.2015.1042197
CitationAla-Eddin Al Moustafa (2015) E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation, Cell Adhesion & Migration, 9:5, 392-393
ISSN1933-6918
URIhttp://hdl.handle.net/10576/4985
AbstractIt is estimated that 10–20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, the role of onco-viruses in cancer progression to a metastatic form is of particular interest. Recent studies reported that E5 and E6/E7 onco-proteins of high-risk HPVs could enhance cancer progression via the initiation of the epithelial–mesenchymal transition (EMT) event. Herein, we discuss the association between E5 as well as E6/E7 of high-risk HPV and cancer progression.
SponsorCanadian Institutes for Health Research, the Cancer Research Society Inc. of Canada, the National Colorectal Cancer Campaign and the Fonds de la Recherche en Sant e du Qu ebec (FRSQ- R eseau du Cancer
Languageen
PublisherTaylor & Francis
Subjecthigh-risk HPV
Subjectgene cooperation
SubjectE6/E7
SubjectE5
Subjectcancer progression
TitleE5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation
TypeArticle
Pagination392-393
Issue Number5
Volume Number9
dc.identifier.essn 1933-6926


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