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AuthorPihíková, Dominika
AuthorKasák, Peter
AuthorTkac, Jan
Available date2016-11-21T10:45:50Z
Publication Date2015-01
Publication NameOpen Chemistryen_US
Identifierhttp://dx.doi.org/10.1515/chem-2015-0082
CitationPihíková D, Kasák P, Tkac J. Glycoprofiling of cancer biomarkers: Label-free electrochemical lectin-based biosensors. Open chemistry. 2015;13(1):636-655.
URIhttp://hdl.handle.net/10576/5032
AbstractGlycosylation of biomolecules is one of the most prevalent post- and co-translational modification in a human body, with more than half of all human proteins being glycosylated. Malignant transformation of cells influences glycosylation machinery resulting in subtle changes of the glycosylation pattern within the cell populations as a result of cancer. Thus, an altered terminal glycan motif on glycoproteins could provide a warning signal about disease development and progression and could be applied as a reliable biomarker in cancer diagnostics. Among all highly effective glycoprofiling tools, label-free electrochemical impedance spectroscopy (EIS)-based biosensors have emerged as especially suitable tool for point-of-care early-stage cancer detection. Herein, we highlight the current challenges in glycoprofiling of various cancer biomarkers by ultrasensitive impedimetric-based biosensors with low sample consumption, low cost fabrication and simple miniaturization. Additionally, this review provides a short introduction to the field of glycomics and lectinomics and gives a brief overview of glycan alterations in different types of cancer.
SponsorSlovak research and development agency APVV 0282-11 and VEGA 2/0162/14 is acknowledged. The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP/2007-2013)/ERC Grant Agreement no 311532 and this work has received funding from the European Union’s Seventh Framework Program for research, technological development and demonstration under grant agreement no 317420.This publication was made possible by NPRP grant # 6-381-1-078 from the Qatar National Research Fund (a member of Qatar Foundation).
Languageen
PublisherDe Gruyter
Subjectglycosylation
Subjectlectins
Subjectelectrochemical impedance spectroscopy
Subjectcancer biomarkers
Subjectbiosensors
TitleGlycoprofiling of cancer biomarkers: Label-free electrochemical lectin-based biosensors
TypeArticle
Pagination636-655
Issue Number1
Volume Number13
dc.identifier.essn 2391-5420


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