The Effects of Statin Therapy on Circulating Levels of Trimethylamine N-oxide: A Systematic Review and Meta-analysis
المؤلف | Jamialahmadi, Tannaz |
المؤلف | Reiner, Željko |
المؤلف | Riahi, Maryam Matbou |
المؤلف | Kesharwani, Prashant |
المؤلف | Eid, Ali H. |
المؤلف | Tayarani-Najaran, Zahra |
المؤلف | Sahebkar, Amirhossein |
تاريخ الإتاحة | 2024-02-06T11:23:27Z |
تاريخ النشر | 2023-10-19 |
اسم المنشور | Current Medicinal Chemistry |
المعرّف | http://dx.doi.org/10.2174/0109298673245069231010065055 |
الاقتباس | Jamialahmadi, T., Reiner, Ž., Kesharwani, P., Eid, A. H., Tayarani-Najaran, Z., & Sahebkar, A. (2023). The Effects of Statin Therapy on Circulating Levels of Trimethylamine N-oxide: A Systematic Review and Meta-analysis. Current Medicinal Chemistry. |
الرقم المعياري الدولي للكتاب | 0929-8673 |
الملخص | Background Gut microbiota is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD) through the metabolites, which can induce atherogenesis. One of these metabolites is trimethylamine N-oxide (TMAO). Some studies indicate that statins do not only decrease LDL-cholesterol and thus ASCVD risk, but they also affect gut microbiota. There are only a few studies on humans suggesting that statins might also decrease TMAO, but their results are not unanimous. This meta-analysis aimed to provide an answer as to whether statins do affect decreasing the plasma levels of atherogenic TMAO. Methods A systematic literature search in PubMed, Scopus, Embase, and Web of Science was performed from inception to January 1st, 2023. To assess the quality of each study included in the meta-analysis, the Cochrane Quality Assessment tool 1 (ROB 1) was used. Comprehensive Meta-Analysis V3 software was used to perform the meta-analysis. The weighted mean difference was also used. A random effects meta-analysis was used to calculate the overall estimate of effect size. In the leave-one-out approach, one study was excluded from each analysis to evaluate the effect of each study on the overall effect size. Results Random-effects meta-analysis of 3 studies including 244 patients demonstrated a significant decrease in plasma TMAO levels after statin treatment (WMD: -1.839, 95% CI: -2.391, -1.287, p<0.001; I2 :0). The reduction in TMAO was robust in the leaveone-out sensitivity analysis. Conclusion Statins might reduce TMAO levels, but there is a need for further evidence from long-term studies taking into account different types and doses of statins. |
اللغة | en |
الناشر | Bentham Science Publishers |
الموضوع | Statin Therapy Trimethylamine N-oxide |
النوع | Article |
ESSN | 1875-533X |
الملفات في هذه التسجيلة
الملفات | الحجم | الصيغة | العرض |
---|---|---|---|
لا توجد ملفات لها صلة بهذه التسجيلة. |
هذه التسجيلة تظهر في المجموعات التالية
-
أبحاث الطب [1418 items ]