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AuthorHabibullah, Mohammad
AuthorJemmieh, Khaleed
AuthorOuda, Amr
AuthorHaider, Mohammad Zulqurnain
AuthorMalki, Mohammed Imad
AuthorElzouki, Abdel-Naser
Available date2024-02-11T09:15:21Z
Publication Date2024
Publication NameFrontiers in Medicine
Identifier10.3389/fmed.2024.1291501
Identifierhttp://dx.doi.org/10.3389/fmed.2024.1291501
CitationHabibullah M, Jemmieh K, Ouda A, Haider MZ, Malki MI and Elzouki A-N (2024) Metabolic-associated fatty liver disease: a selective review of pathogenesis, diagnostic approaches, and therapeutic strategies. Front. Med. 11:1291501. doi: 10.3389/fmed.2024.1291501
URIhttp://hdl.handle.net/10576/51752
AbstractMetabolic associated fatty liver disease (MAFLD) is a novel terminology introduced in 2020 to provide a more accurate description of fatty liver disease associated with metabolic dysfunction. It replaces the outdated term nonalcoholic fatty liver disease (NAFLD) and aims to improve diagnostic criteria and tailored treatment strategies for the disease. NAFLD, the most prevalent liver disease in western industrialized nations, has been steadily increasing in prevalence and is associated with serious complications such as cirrhosis and hepatocellular carcinoma. It is also linked to insulin resistance syndrome and cardiovascular diseases. However, current studies on NAFLD have limitations in meeting necessary histological endpoints. This literature review aims to consolidate recent knowledge and discoveries concerning MAFLD, integrating the diverse aspects of the disease. Specifically, it focuses on analyzing the diagnostic criteria for MAFLD, differentiating it from NAFLD and alcoholic fatty liver disease (AFLD), and exploring the epidemiology, clinical manifestations, pathogenesis, and management approaches associated with MAFLD. The review also explores the associations between MAFLD and other conditions. It discusses the heightened mortality risk associated with MAFLD and its link to chronic kidney disease (CKD), showing that MAFLD exhibits enhanced diagnostic accuracy for identifying patients with CKD compared to NAFLD. The association between MAFLD and incident/prevalent CKD is supported by cohort studies and meta-analyses. This literature review highlights the importance of MAFLD as a distinct terminology for fatty liver disease associated with metabolic dysfunction. The review provides insights into the diagnostic criteria, associations with CKD, and management approaches for MAFLD. Further research is needed to develop more accurate diagnostic tools for advanced fibrosis in MAFLD and to explore the underlying mechanisms linking MAFLD with other conditions. This review serves as a valuable resource for researchers and healthcare professionals seeking a comprehensive understanding of MAFLD.
Languageen
PublisherFrontiers Media
Subjectclinical manifestations
diagnostic criteria
epidemiology
hepatic steatosis
metabolic associated fatty liver disease (MAFLD)
non-alcoholic fatty liver disease (NAFLD)
nonalcoholic steatohepatitis (NASH)
pathogenesis
TitleMetabolic-associated fatty liver disease: a selective review of pathogenesis, diagnostic approaches, and therapeutic strategies.
TypeArticle Review
Volume Number11
ESSN2296-858X
dc.accessType Open Access


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