Colchicine use might be associated with lower mortality in COVID-19 patients: A meta-analysis
Author | Elshafei, Mohamed Nabil |
Author | El-Bardissy, Ahmed |
Author | Khalil, Ahmed |
Author | Danjuma, Mohammed |
Author | Mubasher, Mahmood |
Author | Abubeker, Ibrahim Y. |
Author | Mohamed, Mouhand F.H. |
Available date | 2024-02-14T10:28:46Z |
Publication Date | 2021-06-29 |
Publication Name | European Journal of Clinical Investigation |
Identifier | http://dx.doi.org/10.1111/eci.13645 |
Citation | Elshafei, M. N., El‐Bardissy, A., Khalil, A., Danjuma, M., Mubasher, M., Abubeker, I. Y., & Mohamed, M. F. (2021). Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis. European journal of clinical investigation, 51(9), e13645. |
ISSN | 0014-2972 |
Abstract | Background: Colchicine was recently repurposed for the management of coronavirus disease 2019 (COVID-19). This rapid review and meta-analysis aimed to assess colchicine's impact on mortality outcomes in COVID-19 patients. Materials and Methods: We systematically searched PubMed, EMBASE, Google Scholar since their inception till 25/03/2021 for observational or controlled studies that reported mortality as an outcome. The mortality odd ratios were generated with their corresponding 95% confidence intervals utilizing the random-effects model. Results: Nine studies comprising 5522 patients met our inclusion criteria. Our meta-analysis revealed significantly lower mortality in the colchicine group (OR 0.35, 95% CI 0.25-0.48, I2 0%) compared with controls. A subgroup analysis limited to hospitalized patients (OR 0.35, 95% CI 0.25-0.50, I2 0%) revealed similarly lower mortality in the colchicine group. Conclusions: This meta-analysis suggests a mortality benefit with colchicine when used in the treatment of COVID-19 patients. The majority of included studies were observational; thus, the findings of this review need to be further supported by the results of ongoing trials. |
Sponsor | Open Access funding provided by the Qatar National Library. |
Language | en |
Publisher | Wiley-Blackwell |
Subject | colchicine coronavirus disease 2019 COVID-19 mortality SARS-CoV-2 |
Type | Article |
Issue Number | 9 |
Volume Number | 51 |
ESSN | 1365-2362 |
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