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المؤلفAbdul Karim, Mustafa
المؤلفAl-Baz, Nadeen
المؤلفOuanes, Sami
المؤلفAlabdulla, Majid
المؤلفHaddad, Peter M.
تاريخ الإتاحة2024-03-04T03:41:15Z
تاريخ النشر2021
اسم المنشورBMC Psychiatry
المصدرScopus
الرقم المعياري الدولي للكتاب1471244X
معرّف المصادر الموحدhttp://dx.doi.org/10.1186/s12888-021-03175-5
معرّف المصادر الموحدhttp://hdl.handle.net/10576/52587
الملخصBackground: Restless Legs Syndrome (RLS) is a sensorimotor disorder characterized by unpleasant and distressing sensations in the lower limbs that are more pronounced in the evening, commence or worsen at rest, and show partial or complete relief following movement. It can occur as a primary disorder, secondary to medical conditions or treatment with medications including but not limited to antidepressants or antipsychotics. Case presentation: A 32-year old man with major depressive disorder showed partial response to Escitalopram 10 mg daily. Agomelatine 25 mg at night was added to Escitalopram to treat his residual depressive symptoms, namely insomnia and tiredness. Within two days he developed restlessness and unpleasant sensations in his legs which were worse at night. Symptom severity increased over the following days, prompting an urgent consultation a week later. The patient's presentation met the criteria for RLS. Agomelatine was discontinued leaving the patient on Escitalopram alone. The patient's symptoms improved within 24 h of stopping Agomelatine, with complete resolution four days later. There was no recurrence of RLS during follow-up. The patient scored 6 on Naranjo's adverse drug reaction probability scale, indicating a probable adverse drug reaction caused by Agomelatine. Conclusions: To the best of our knowledge, this is the first case report of suspected Agomelatine-induced RLS. Clinicians need to be aware of RLS to enable prompt diagnosis and management. We suggest adding Agomelatine to the list of agents that can potentially induce RLS.
اللغةen
الناشرBioMed Central Ltd
الموضوعAgomelatine
Antidepressants
Restless legs syndrome
العنوانSuspected Agomelatine-induced restless legs syndrome: a case report
النوعArticle
رقم العدد1
رقم المجلد21
dc.accessType Open Access


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