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AuthorAbdul Karim, Mustafa
AuthorAl-Baz, Nadeen
AuthorOuanes, Sami
AuthorAlabdulla, Majid
AuthorHaddad, Peter M.
Available date2024-03-04T03:41:15Z
Publication Date2021
Publication NameBMC Psychiatry
ResourceScopus
ISSN1471244X
URIhttp://dx.doi.org/10.1186/s12888-021-03175-5
URIhttp://hdl.handle.net/10576/52587
AbstractBackground: Restless Legs Syndrome (RLS) is a sensorimotor disorder characterized by unpleasant and distressing sensations in the lower limbs that are more pronounced in the evening, commence or worsen at rest, and show partial or complete relief following movement. It can occur as a primary disorder, secondary to medical conditions or treatment with medications including but not limited to antidepressants or antipsychotics. Case presentation: A 32-year old man with major depressive disorder showed partial response to Escitalopram 10 mg daily. Agomelatine 25 mg at night was added to Escitalopram to treat his residual depressive symptoms, namely insomnia and tiredness. Within two days he developed restlessness and unpleasant sensations in his legs which were worse at night. Symptom severity increased over the following days, prompting an urgent consultation a week later. The patient's presentation met the criteria for RLS. Agomelatine was discontinued leaving the patient on Escitalopram alone. The patient's symptoms improved within 24 h of stopping Agomelatine, with complete resolution four days later. There was no recurrence of RLS during follow-up. The patient scored 6 on Naranjo's adverse drug reaction probability scale, indicating a probable adverse drug reaction caused by Agomelatine. Conclusions: To the best of our knowledge, this is the first case report of suspected Agomelatine-induced RLS. Clinicians need to be aware of RLS to enable prompt diagnosis and management. We suggest adding Agomelatine to the list of agents that can potentially induce RLS.
Languageen
PublisherBioMed Central Ltd
SubjectAgomelatine
Antidepressants
Restless legs syndrome
TitleSuspected Agomelatine-induced restless legs syndrome: a case report
TypeArticle
Issue Number1
Volume Number21
dc.accessType Open Access


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