| Author | Andreoli, María |
| Author | Fittipaldi, Antonela S. |
| Author | Castrogiovanni, Daniel |
| Author | De Francesco, Pablo N. |
| Author | Valdivia, Spring |
| Author | Heredia, Florencia |
| Author | Ribet-Travers, Carole |
| Author | Mendez, Ignacio |
| Author | Fasano, María V. |
| Author | Schioth, Helgi B. |
| Author | Doi, Suhail A. |
| Author | Habib, Abdella M. |
| Author | Perello, Mario |
| Available date | 2024-03-13T13:38:03Z |
| Publication Date | 2023 |
| Publication Name | European Journal of Nutrition |
| Resource | Scopus |
| ISSN | 14366207 |
| URI | http://dx.doi.org/10.1007/s00394-023-03304-8 |
| URI | http://hdl.handle.net/10576/53044 |
| Abstract | Purpose
The liver-expressed antimicrobial peptide 2 (LEAP2) is a newly recognized peptide hormone that acts via the growth hormone secretagogue receptor (GHSR) blunting the effects of ghrelin and displaying ghrelin-independent actions. Since the implications of LEAP2 are beginning to be elucidated, we investigated if plasma LEAP2 concentration varies with feeding status or sex and whether it is associated with glucose metabolism and appetite sensations.
Methods
We performed a single test meal study, in which plasma concentrations of LEAP2, ghrelin, insulin and glucose as well as visual analogue scales for hunger, desire to eat, prospective food consumption, fullness were assessed before and 60 min after breakfast in 44 participants (n = 21 females) with normal weight (NW) or overweight/obesity (OW/OB).
Results
Pre-prandial plasma LEAP2 concentration was ~ 1.6-fold higher whereas ghrelin was ~ 2.0-fold lower in individuals with OW/OB (p < 0.001) independently of sex. After adjusting for body mass index (BMI) and sex, pre-prandial plasma LEAP2 concentration displayed a direct relationship with BMI (β: 0.09; 95%CI: 0.05, 0.13; p < 0.001), fat mass (β: 0.05; 95%CI: 0.01, 0.09; p = 0.010) and glycemia (β: 0.24; 95%CI: 0.05, 0.43; p = 0.021), whereas plasma ghrelin concentration displayed an inverse relationship with BMI and fat mass but not with glycemia. Postprandial plasma LEAP2 concentration increased ~ 58% in females with OW/OB (p = 0.045) but not in females with NW or in males. Pre-prandial plasma LEAP2 concentration displayed an inverse relationship with hunger score (β: − 11.16; 95% CI: − 18.52, − 3.79; p = 0.004), in a BMI-, sex- and ghrelin-independent manner.
Conclusions
LEAP2 emerges as a key hormone implicated in the regulation of metabolism and appetite in humans.
Trial registration
The study was retrospectively registered in clinicaltrials.gov (April 2023). ClinicalTrials.gov Identifier: NCT05815641. |
| Sponsor | This work was supported by grants from Fondo para la Investigación Científica y Tecnológica (FONCyT, PICT2017-3196, PICT2019-3054 and PICT2020-3270 to MP; PICT2019-256 to MFA), CONICET (PUE105 to MP), The National Qatar Research Foundation (NPRP13S-0209-200315 to AMH, MP and SAD) and Fundación Florencio Fiorini (to MFA). |
| Language | en |
| Publisher | Springer Science and Business Media Deutschland GmbH |
| Subject | Appetite sensations' Ghrelin' Hunger' Insulin resistance' LEAP2' Obesity
|
| Title | Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner |
| Type | Article |
|
dc.accessType
| Abstract Only |
