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AuthorZaki, Hany A.
AuthorBensliman, Soumaya
AuthorBashir, Khalid
AuthorIftikhar, Haris
AuthorFayed, Mohamed H.
AuthorSalem, Waleed
AuthorElmoheen, Amr
AuthorYigit, Yavuz
Available date2024-04-25T06:20:12Z
Publication Date2024
Publication NameSystematic Reviews
ResourceScopus
ISSN20464053
URIhttp://dx.doi.org/10.1186/s13643-023-02432-w
URIhttp://hdl.handle.net/10576/54231
AbstractBackground Differentiating sepsis from non-infectious systemic inflammatory response syndrome (SIRS) is challenging. Biomarkers like procalcitonin (PCT) aid early risk assessment and guide antibiotic use. This study aims to ascertain PCT's accuracy as a sepsis biomarker among adult emergency department admissions. Method The PRISMA guidelines were followed to search for relevant articles in five electronic databases between April 14th and August 4th, 2023: PubMed, Cochrane Library, ProQuest, EMBASEs, and ScienceDirect. Studies had to be published in English to avoid directly translating scientific terms. Besides, the inclusion criteria were based on the diagnosis of sepsis in adult patients admitted to an emergency department. QUADAS-2 tool provided by the Review Manager version 5.4.1 was utilized to assess the risk of bias in included studies. STATA (v. 16) software was used to perform the meta-analysis. Results Ten of 2457 studies were included. We sampled 2980 adult sepsis patients for the under-investigated role of PCT in ED sepsis diagnosis. PCT emerged as the primary early diagnostic biomarker with high levels (29.3 ± 85.3 ng/mL) in sepsis patients. Heterogeneity in outcomes, possibly due to bias in cohort and observational studies, was observed. Conclusion PCT tests offer moderate accuracy in diagnosing sepsis and stand out for rapidly and precisely distinguishing between viral and bacterial inflammations.
Languageen
PublisherBioMed Central Ltd
Subjectantibiotic agent
biological marker
procalcitonin
biological marker
procalcitonin
APACHE
critically ill patient
diagnostic test accuracy study
emergency ward
human
meta analysis
predictive value
Review
risk assessment
sensitivity and specificity
sepsis
Staphylococcus aureus
systematic review
systemic inflammatory response syndrome
adult
hospital emergency service
hospitalization
sepsis
Adult
Biomarkers
Emergency Service, Hospital
Hospitalization
Humans
Procalcitonin
Sepsis
TitleAccuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis
TypeArticle Review
Issue Number1
Volume Number13


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