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AuthorAl Ashmar, Sarah
AuthorAnwardeen, Najeha Rizwana
AuthorAnlar, Gulsen Guliz
AuthorPedersen, Shona
AuthorElrayess, Mohamed A.
AuthorZeidan, Asad
Available date2024-04-25T06:20:13Z
Publication Date2024
Publication NameFrontiers in Cardiovascular Medicine
ResourceScopus
ISSN2297055X
URIhttp://dx.doi.org/10.3389/fcvm.2024.1284114
URIhttp://hdl.handle.net/10576/54241
AbstractIntroduction: Pre-hypertension is a prevalent condition among the adult population worldwide. It is characterized by asymptomatic elevations in blood pressure beyond normal levels but not yet reaching the threshold for hypertension. If left uncontrolled, pre-hypertension can progress to hypertension, thereby increasing the risk of serious complications such as heart disease, stroke, kidney damage, and others. Objective: The precise mechanisms driving the progression of hypertension remain unknown. Thus, identifying the metabolic changes associated with this condition can provide valuable insights into potential markers or pathways implicated in the development of hypertension. Methods: In this study, we utilized untargeted metabolomics profiling, which examines over 1,000 metabolites to identify novel metabolites contributing to the progression from pre-hypertension to hypertension. Data were collected from 323 participants through Qatar Biobank. Results: By comparing metabolic profiles between pre-hypertensive, hypertensive and normotensive individuals, six metabolites including stearidonate, hexadecadienoate, N6-carbamoylthreonyladenosine, 9 and 13-S-hydroxyoctadecadienoic acid (HODE), 2,3-dihydroxy-5-methylthio- 4-pentenoate (DMTPA), and linolenate were found to be associated with increased risk of hypertension, in both discovery and validation cohorts. Moreover, these metabolites showed a significant diagnostic performance with area under curve >0.7. Conclusion: These findings suggest possible biomarkers that can predict the risk of progression from pre-hypertension to hypertension. This will aid in early detection, diagnosis, and management of this disease as well as its associated complications.
SponsorThis paper was made possible by Qatar University grants award UREP27-050-3-020 from Qatar National Research Fund (a member of Qatar Foundation) to AZ. Acknowledgments
Languageen
PublisherFrontiers Media SA
Subjectbiomarkers
disease progression
hypertension
metabolic profiling
pre-hypertension
TitleMetabolomic profiling reveals key metabolites associated with hypertension progression
TypeArticle
Volume Number11
dc.accessType Open Access


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