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المؤلفMrlik, Miroslav
المؤلفSobolciak, P.
المؤلفKrupa, I.
المؤلفKasak, Peter
تاريخ الإتاحة2024-05-01T06:32:51Z
تاريخ النشر2018
اسم المنشورEmergent Materials
المصدرScopus
المعرّفhttp://dx.doi.org/10.1007/s42247-018-0004-2
الرقم المعياري الدولي للكتاب25225731
معرّف المصادر الموحدhttp://hdl.handle.net/10576/54524
الملخصIn this study, the interaction of a photoswitchable carboxybetaine ester-based polymer with mucus and cellulose sulfate was elucidated, showing light-controllable viscoelastic properties. This polymer contains photolabile o-nitrobenzyl ester moieties, allowing transformation from its polycationic form to a charge-balanced nontoxic polyzwitterionic form upon photolysis by irradiation at 365 nm. Rheological studies revealed that the polycationic form of the polymer interacts with mucus and cellulose sulfate to create a physically crosslinked hydrogel based primarily on polyionic complexation and partially on hydrogen bonding. In these cases, a dramatic change in the rheological synergism was confirmed for mucus-based and cellulose sulfate-based systems. Rheological synergism with the polycationic carboxybetaine ester sample reached nearly 4 and 3.8, while it decreased with the charge-balanced zwitterionic sample to 0.3 and 0.7 after irradiation of the mucus-based and cellulose sulfate-based systems, respectively. Disruption of the interaction during light-induced transformation was on-line monitored and showed a 3 and 3.3 times decrease in the elastic modulus for the mucus-based and cellulose sulfate-based systems, respectively. These properties suggest possible biomedical applications, such as spatially controlled drug release or laparoscopic utilization.
راعي المشروعThe authors thank Dr. I. Lacik (Polymer Institute, the Slovak Academy of Science, Slovakia) for generously providing the laboratory facilities in the initial stage of the investigation. This publication was supported by Qatar University Grant QUUG-CAM-2017-1. This work was made possible by NPRP grant No. 7 - 1724 - 3 - 438 from the Qatar National Research Fund (a member of The Qatar Foundation). The statements made herein are solely the responsibility of the authors. This work was also supported by the Ministry of Education, Youth and Sports of the Czech Republic - program NPU I (LO1504).
اللغةen
الناشرSpringer Nature
الموضوعCarboxybetaine ester
Cellulose sulfate
Mucus
Photolabile polymers
Zwitterionic polymers
العنوانLight-controllable viscoelastic properties of a photolabile carboxybetaine ester-based polymer with mucus and cellulose sulfate
النوعArticle
الصفحات35-45
رقم العدد1-2
رقم المجلد1
dc.accessType Abstract Only


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