Show simple item record

AuthorMrlik, Miroslav
AuthorSobolciak, P.
AuthorKrupa, I.
AuthorKasak, Peter
Available date2024-05-01T06:32:51Z
Publication Date2018
Publication NameEmergent Materials
ResourceScopus
Identifierhttp://dx.doi.org/10.1007/s42247-018-0004-2
ISSN25225731
URIhttp://hdl.handle.net/10576/54524
AbstractIn this study, the interaction of a photoswitchable carboxybetaine ester-based polymer with mucus and cellulose sulfate was elucidated, showing light-controllable viscoelastic properties. This polymer contains photolabile o-nitrobenzyl ester moieties, allowing transformation from its polycationic form to a charge-balanced nontoxic polyzwitterionic form upon photolysis by irradiation at 365 nm. Rheological studies revealed that the polycationic form of the polymer interacts with mucus and cellulose sulfate to create a physically crosslinked hydrogel based primarily on polyionic complexation and partially on hydrogen bonding. In these cases, a dramatic change in the rheological synergism was confirmed for mucus-based and cellulose sulfate-based systems. Rheological synergism with the polycationic carboxybetaine ester sample reached nearly 4 and 3.8, while it decreased with the charge-balanced zwitterionic sample to 0.3 and 0.7 after irradiation of the mucus-based and cellulose sulfate-based systems, respectively. Disruption of the interaction during light-induced transformation was on-line monitored and showed a 3 and 3.3 times decrease in the elastic modulus for the mucus-based and cellulose sulfate-based systems, respectively. These properties suggest possible biomedical applications, such as spatially controlled drug release or laparoscopic utilization.
SponsorThe authors thank Dr. I. Lacik (Polymer Institute, the Slovak Academy of Science, Slovakia) for generously providing the laboratory facilities in the initial stage of the investigation. This publication was supported by Qatar University Grant QUUG-CAM-2017-1. This work was made possible by NPRP grant No. 7 - 1724 - 3 - 438 from the Qatar National Research Fund (a member of The Qatar Foundation). The statements made herein are solely the responsibility of the authors. This work was also supported by the Ministry of Education, Youth and Sports of the Czech Republic - program NPU I (LO1504).
Languageen
PublisherSpringer Nature
SubjectCarboxybetaine ester
Cellulose sulfate
Mucus
Photolabile polymers
Zwitterionic polymers
TitleLight-controllable viscoelastic properties of a photolabile carboxybetaine ester-based polymer with mucus and cellulose sulfate
TypeArticle
Pagination35-45
Issue Number1-2
Volume Number1
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record