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AuthorKrishnasamy, Vinotha
AuthorNair, Gayathri Geetha
AuthorSha, Mizaj Shabil
AuthorKannan, Karthik
AuthorAl-maadeed, Somaya
AuthorMuthalif, Asan G.A.
AuthorSadasivuni, Kishor Kumar
Available date2024-05-14T03:51:40Z
Publication Date2023
Publication NameMacromolecular Symposia
ResourceScopus
Identifierhttp://dx.doi.org/10.1002/masy.202200151
ISSN10221360
URIhttp://hdl.handle.net/10576/54915
AbstractDopamine plays a significant role in the proper functioning of the central nervous system. Hence, the ability to sense levels of dopamine is pivotal in diagnosis and treatment procedures. For sensing dopamine, a mixed metal oxide nanocomposite (NC) of copper oxide-nickel oxide/reduced graphene oxide (CuO-NiO/rGO) is fabricated by the sol–gel method, and it is used to modify the glassy carbon electrode. The structural and morphological characterizations are done by X-ray diffraction (XRD), Energy dispersive X-ray (EDAX), Raman, and Scanning electron microscopy (SEM). XRD results exhibit monoclinic CuO, cubic NiO, and hexagonal rGO structures. The Raman studies confirm the D and G bands for rGO. Different electrochemical techniques are used to examine the efficacy of nanocomposite in detecting dopamine. The CuO-NiO metal oxide NC response compared with the CuO-NiO/rGO NC shows a better response by rGO containing nanocomposite. Further, the chronoamperometric method is employed, and the diffusion coefficient is calculated as 1.04 × 10−6 cm2 s−1. The differential pulse voltammetry is carried out to measure the nanocomposite's sensitivity and detection limit (LOD). The catalyst exhibits a sensitivity of 7.2 µA cm−2 mM−1 and a LOD of 0.006 µM. The composite can be used as a flexible skin patch sensor to predict abnormal dopamine levels such as Parkinson's disease.
SponsorThis publication was supported by Qatar University internal grant No. QUCG-CAM-21/22-1. The findings herein are solely the responsibility of the authors.
Languageen
PublisherJohn Wiley and Sons Inc
Subjectamperometric studies
mixed metal oxide nanocomposite
proton conductor
voltammetry
TitleA Promising Electrochemical Sensor Platform for the Detection of Dopamine Using CuO-NiO/rGO Composite
TypeArticle
Issue Number1
Volume Number412


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