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AuthorKaur, Prabhjit
AuthorRizk, Nasser
AuthorIbrahim, Sereen
AuthorLuo, Yue
AuthorYounes, Noura
AuthorPerry, Brian
AuthorDennis, Kevin
AuthorZirie, Mahmoud
AuthorLuta, George
AuthorCheema, Amrita K.
Available date2024-05-22T11:14:57Z
Publication Date2013-02
Publication NameMolecular BioSystems
Identifierhttp://dx.doi.org/10.1039/c2mb25384d
CitationKaur, P., Rizk, N., Ibrahim, S., Luo, Y., Younes, N., Perry, B., ... & Cheema, A. K. (2013). Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes. Molecular BioSystems, 9(2), 307-317.
ISSN1742-206X
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84872084948&origin=inward
URIhttp://hdl.handle.net/10576/55299
AbstractType 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using a combination of untargeted and targeted metabolomic profiling approach we were able to delineate significantly altered metabolites in the diabetic (T2DM) group. Our results indicate significant perturbations in amino acid metabolism, TCA cycle and glycerol-phospholipid metabolism possibly impacting the overall glucose homeostasis in T2DM. A systems approach offers promise towards identification of clinically relevant markers of T2DM and novel molecular targets to foster drug discovery for effective therapeutic development for diabetes. © 2013 The Royal Society of Chemistry.
SponsorNational Cancer Institute - grant No. [P30CA051008].
Languageen
PublisherRoyal Society of Chemistry
Subjectbiological marker
Diabetes Mellitus
TitleQuantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes
TypeArticle
Pagination307-317
Issue Number2
Volume Number9
ESSN1742-2051


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