Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes
التاريخ
2013-02المؤلف
Kaur, PrabhjitRizk, Nasser
Ibrahim, Sereen
Luo, Yue
Younes, Noura
Perry, Brian
Dennis, Kevin
Zirie, Mahmoud
Luta, George
Cheema, Amrita K.
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
Type 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using a combination of untargeted and targeted metabolomic profiling approach we were able to delineate significantly altered metabolites in the diabetic (T2DM) group. Our results indicate significant perturbations in amino acid metabolism, TCA cycle and glycerol-phospholipid metabolism possibly impacting the overall glucose homeostasis in T2DM. A systems approach offers promise towards identification of clinically relevant markers of T2DM and novel molecular targets to foster drug discovery for effective therapeutic development for diabetes. © 2013 The Royal Society of Chemistry.
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