Show simple item record

AuthorYounes, Salma
AuthorNicolai, Eleonora
AuthorPieri, Massimo
AuthorBernardini, Sergio
AuthorDaas, Hanin I
AuthorAl-Sadeq, Duaa W
AuthorYounes, Nadin
AuthorShurrab, Farah M
AuthorNizamuddin, Parveen B
AuthorHumaira, Fathima
AuthorAl-Dewik, Nader
AuthorYassine, Hadi M
AuthorAbu-Raddad, Laith J
AuthorIsmail, Ahmed
AuthorNasrallah, Gheyath K
Available date2024-05-26T04:23:12Z
Publication Date2024-05-01
Publication NameInfluenza and other Respiratory Viruses
Identifierhttp://dx.doi.org/10.1111/irv.13290
CitationYounes, S., Nicolai, E., Pieri, M., Bernardini, S., Daas, H., Al-Sadeq, D., Younes, N., Shurrab, F., Nizamuddin, P., Humaira, F., Al-Dewik, N., Yassine, H., Abu-Raddad, L., Ismail, A. and Nasrallah, G. (2024), Follow-Up and Comparative Assessment of SARS-CoV-2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA-1273 Heterologous Booster Vaccination. Influenza Other Respi Viruses, 18: e13290. https://doi.org/10.1111/irv.13290
ISSN17502640
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85192110589&origin=inward
URIhttp://hdl.handle.net/10576/55349
AbstractBackground: Priming with ChAdOx1 followed by heterologous boosting is considered in several countries. Nevertheless, analyses comparing the immunogenicity of heterologous booster to homologous primary vaccination regimens and natural infection are lacking. In this study, we aimed to conduct a comparative assessment of the immunogenicity between homologous primary vaccination regimens and heterologous prime-boost vaccination using BNT162b2 or mRNA-1273. Methods: We matched vaccinated naïve (VN) individuals (n = 673) with partial vaccination (n = 64), primary vaccination (n = 590), and primary series plus mRNA vaccine heterologous booster (n = 19) with unvaccinated naturally infected (NI) individuals with a documented primary SARS-CoV-2 infection (n = 206). We measured the levels of neutralizing total antibodies (NTAbs), total antibodies (TAbs), anti-S-RBD IgG, and anti-S1 IgA titers. Results: Homologous primary vaccination with ChAdOx1 not only showed less potent NTAb, TAb, anti-S-RBD IgG, and anti-S1 IgA immune responses compared to primary BNT162b2 or mRNA-1273 vaccination regimens (p < 0.05) but also showed ~3-fold less anti-S1 IgA response compared to infection-induced immunity (p < 0.001). Nevertheless, a heterologous booster led to an increase of ~12 times in the immune response when compared to two consecutive homologous ChAdOx1 immunizations. Furthermore, correlation analyses revealed that both anti-S-RBD IgG and anti-S1 IgA significantly contributed to virus neutralization among NI individuals, particularly in symptomatic and pauci-symptomatic individuals, whereas among VN individuals, anti-S-RBD IgG was the main contributor to virus neutralization. Conclusion: The results emphasize the potential benefit of using heterologous mRNA boosters to increase antibody levels and neutralizing capacity particularly in patients who received primary vaccination with ChAdOx1.
SponsorGKN would like to acknowledge the funding from WHO grant number COVID-19-22-43 and Qatar University grant No. QUCG-BRC-23/24-170. This work was made possible by grant number UREP28-173-3-057 from the Qatar National Research Fund (a member of Qatar Foundation). The statements made herein are solely the responsibility of the authors.
Languageen
PublisherWiley
Subjectanti-S-RBD IgG
anti-S1-IgA
antibodies
booster
COVID-19
immune response
neutralizing antibody
vaccination
TitleFollow-Up and Comparative Assessment of SARS-CoV-2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA-1273 Heterologous Booster Vaccination
TypeArticle
Issue Number5
Volume Number18
ESSN1750-2659
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record