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المؤلفYeşil Sarsmaz, Hayrunnisa
المؤلفGürgen, Seren Gülşen
المؤلفCansu, Ali
المؤلفTürkmen, Süha
المؤلفGündüz, Abdülkadir
تاريخ الإتاحة2024-05-28T04:59:12Z
تاريخ النشر2024
اسم المنشورFood and Chemical Toxicology
المصدرScopus
المعرّفhttp://dx.doi.org/10.1016/j.fct.2024.114634
الرقم المعياري الدولي للكتاب2786915
معرّف المصادر الموحدhttp://hdl.handle.net/10576/55562
الملخصThe purpose of this study is to determine the effects of grayanotoxin in mad honey on ovarian tissue folliculogenesis in terms of cell death and nitric oxide expression. Three groups of 18 female Sprague-Dawley rats were formed. The first group received mad honey (80 mg/kg), the second group received normal honey (80 mg/kg), and the third group was the control. The first and second groups received normal and mad honey by oral gavage for 30 days before being sacrificed under anesthesia. Caspase 3 immunostaining showed a moderate to strong response, particularly in the mad honey group. In the mad honey group, immunostaining for caspase 8 and caspase 9 revealed a moderate immunoreaction in the granulosa cells of the Graaf follicles. The majority of Graaf follicles exhibited TUNEL positive in the mad honey group. The iNOS immunoreaction revealed a high level of expression in the mad honey group. In all three groups, eNOS immunostaining showed weak reactivity. According to the findings of apoptotic and nitric oxide marker expression, it was determined that mad honey may result in an increase in follicular atresia in ovarian follicles when compared to normal honey and control groups.
اللغةen
الناشرElsevier
الموضوعApoptosis
Grayonotoxin
Immunohistochemistry
Mad honey
Normal honey
Ovary
العنوانThe relationship between oxidative stress and apoptosis of histopathological changes in the ovary made by mad honey containing grayanotoxin
النوعArticle
رقم المجلد187
dc.accessType Abstract Only


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