Show simple item record

AuthorYeşil Sarsmaz, Hayrunnisa
AuthorGürgen, Seren Gülşen
AuthorCansu, Ali
AuthorTürkmen, Süha
AuthorGündüz, Abdülkadir
Available date2024-05-28T04:59:12Z
Publication Date2024
Publication NameFood and Chemical Toxicology
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.fct.2024.114634
ISSN2786915
URIhttp://hdl.handle.net/10576/55562
AbstractThe purpose of this study is to determine the effects of grayanotoxin in mad honey on ovarian tissue folliculogenesis in terms of cell death and nitric oxide expression. Three groups of 18 female Sprague-Dawley rats were formed. The first group received mad honey (80 mg/kg), the second group received normal honey (80 mg/kg), and the third group was the control. The first and second groups received normal and mad honey by oral gavage for 30 days before being sacrificed under anesthesia. Caspase 3 immunostaining showed a moderate to strong response, particularly in the mad honey group. In the mad honey group, immunostaining for caspase 8 and caspase 9 revealed a moderate immunoreaction in the granulosa cells of the Graaf follicles. The majority of Graaf follicles exhibited TUNEL positive in the mad honey group. The iNOS immunoreaction revealed a high level of expression in the mad honey group. In all three groups, eNOS immunostaining showed weak reactivity. According to the findings of apoptotic and nitric oxide marker expression, it was determined that mad honey may result in an increase in follicular atresia in ovarian follicles when compared to normal honey and control groups.
Languageen
PublisherElsevier
SubjectApoptosis
Grayonotoxin
Immunohistochemistry
Mad honey
Normal honey
Ovary
TitleThe relationship between oxidative stress and apoptosis of histopathological changes in the ovary made by mad honey containing grayanotoxin
TypeArticle
Volume Number187
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record