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المؤلفJohnston, Amy N.B.
المؤلفPark, Joon
المؤلفDoi, Suhail A.
المؤلفSharman, Vicki
المؤلفClark, Justin
المؤلفRobinson, Jemma
المؤلفCrilly, Julia
تاريخ الإتاحة2017-06-11T08:05:30Z
تاريخ النشر2017-01
اسم المنشورClinical Therapeutics
المعرّفhttp://dx.doi.org/10.1016/j.clinthera.2016.12.003
الاقتباسAmy N.B. Johnston, Joon Park, Suhail A. Doi, Vicki Sharman, Justin Clark, Jemma Robinson, Julia Crilly, Effect of Immediate Administration of Antibiotics in Patients With Sepsis in Tertiary Care: A Systematic Review and Meta-analysis, Clinical Therapeutics, Volume 39, Issue 1, January 2017, Pages 190-202.e6
الرقم المعياري الدولي للكتاب01492918
معرّف المصادر الموحدhttp://www.sciencedirect.com/science/article/pii/S014929181630916X
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5559
الملخصPurpose The goal of this review was to synthesize existing evidence regarding outcomes (mortality) for patients who present to the emergency department, are administered antibiotics immediately (within 1 hour) or later (>1 hour), and are diagnosed with sepsis. Methods A search of PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and CINAHL, using the MeSH descriptors “sepsis,” “systemic inflammatory response syndrome,” “mortality,” “emergency,” and “antibiotics,” was performed to identify studies reporting time to antibiotic administration and mortality outcome in patients with sepsis. The included studies (published in English between 1990 and 2016) listed patient mortality based on time to antibiotic administration. Studies were evaluated for methodologic quality, and data were extracted by using a data extraction form tailored to this study. From an initial pool of 582 potentially relevant studies, 11 studies met our inclusion criteria, 10 of which had quantitative data for meta-analysis. Three different models (a random effects model, a bias-adjusted quality-effects [synthetic bias] model, and an inverse variance heterogeneity model) were used to perform the meta-analysis. Findings The pooled results suggest a significant 33% reduction in mortality odds for immediate (within 1 hour) compared with later (>1 hour) antibiotic administration (OR, 0.67 [95% CI, 0.59–0.75]) in patients with sepsis. Implications Immediate antibiotic administration (<1 hour) seemed to reduce patient mortality. There was some minor negative asymmetry suggesting that the evidence may be biased toward the direction of effect. Nevertheless, this study provides strong evidence for early, comprehensive, sepsis management in the emergency department.
اللغةen
الناشرElsevier
الموضوعantibiotics
emergency services
medication appropriateness
mortality
sepsis
systemic inflammatory response syndrome
العنوانEffect of Immediate Administration of Antibiotics in Patients With Sepsis in Tertiary Care: A Systematic Review and Meta-analysis
النوعArticle
الصفحات190-202
رقم العدد1
رقم المجلد39
dc.accessType Abstract Only


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