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AuthorFerraz, Daniel Lobato Ferreira
AuthorDos Santos, Erison Santana
AuthorPedroso, Caique Mariano
AuthorSilva, Brunno Santos de Freitas
AuthorKujan, Omar
AuthorSalo, Tuula Anneli
AuthorMalki, Mohammed I
AuthorJuteau, Susanna
AuthorVargas, Pablo Agustin
AuthorLopes, Marcio Ajudarte
AuthorSantos-Silva, Alan Roger
Available date2024-07-09T05:08:52Z
Publication Date2024-06-30
Publication NameOral Diseases
Identifierhttp://dx.doi.org/10.1111/odi.15052
CitationFerraz, D. L. F., dos Santos, E. S., Pedroso, C. M., Silva, B. S. d. F., Kujan, O., Salo, T. A., Malki, M. I., Juteau, S., Vargas, P. A., Lopes, M. A., & Santos-Silva, A. R. (2024). Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis. Oral Diseases, 00, 1–9. https://doi.org/10.1111/odi.15052
ISSN1354-523X
URIhttp://hdl.handle.net/10576/56517
AbstractHistopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes. The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design. Forty-six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta-analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia. No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.
Languageen
PublisherJohn Wiley & Sons Ltd
Subjectepithelial dysplasia
histopathological grading
intraepithelial neoplasia
precancerous conditions
systematic review
TitleHistopathological risk assessment in multisite epithelial dysplasia: A meta-analysis.
TypeArticle Review
ESSN1601-0825
dc.accessType Full Text


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