Show simple item record

AuthorChemaitelly, Hiam
AuthorAkhtar, Naveed
AuthorJerdi, Salman Al
AuthorKamran, Saadat
AuthorJoseph, Sujatha
AuthorMorgan, Deborah
AuthorUy, Ryan
AuthorAbid, Fatma B.
AuthorAl-Khal, Abdullatif
AuthorBertollini, Roberto
AuthorAbou-Samra, Abdul-Badi
AuthorButt, Adeel A.
AuthorAbu-Raddad, Laith J.
Available date2024-08-28T04:23:41Z
Publication Date2024
Publication NameInternational Journal of Infectious Diseases
ResourceScopus
ISSN12019712
URIhttp://dx.doi.org/10.1016/j.ijid.2024.107095
URIhttp://hdl.handle.net/10576/58223
AbstractObjective: This study investigated the association between Coronavirus Disease 2019 mRNA vaccination and stroke in Qatar. Methods: Between December 1, 2020, and April 11, 2023, a matched case-control study was conducted to investigate the association between 3036 acute stroke cases and 3036 controls drawn from the entire population of Qatar. Results: The adjusted odds ratio (aOR) for vaccination among cases compared to controls was 0.87 (95% CI: 0.75-1.00). The aOR was 0.74 (95% CI: 0.45-1.23) for a single vaccine dose, 0.87 (95% CI: 0.73-1.04) for primary-series vaccination (two doses), and 0.91 (95% CI: 0.66-1.25) for booster vaccination (three or more doses). The aOR was 0.87 (95% CI: 0.72-1.04) for BNT162b2 and 0.86 (95% CI: 0.67-1.11) for mRNA-1273. Subgroup analyses, considering different durations since vaccination, also demonstrated no association. Subgroup analyses based on nationality, age, number of coexisting conditions, or prior infection status yielded similar results. Subgroup analysis, stratified by stroke type, suggested an association between vaccination and cerebral venous sinus thrombosis (aOR of 2.50 [95% CI: 0.97-6.44]), but it did not reach statistical significance. Conclusion: There was no evidence of an increased risk of stroke following vaccination, both in the short term and in the long term, extending beyond a year after receiving the vaccine.
SponsorThe authors are grateful for institutional salary support from the Biomedical Research Program and the Biostatistics, Epidemiology, and Biomathematics Research Core, both at Weill Cornell Medicine-Qatar, as well as for institutional salary support provided by the Ministry of Public Health and Hamad Medical Corporation. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the article. Statements made herein are solely the responsibility of the authors. We acknowledge the many dedicated individuals at Hamad Medical Corporation, the Ministry of Public Health, the Primary Health Care Corporation, Qatar Biobank, Sidra Medicine, and Weill Cornell Medicine-Qatar for their diligent efforts and contributions to make this study possible.
Languageen
PublisherElsevier
SubjectCase control
COVID-19
Epidemiology
Qatar
SARS-CoV-2
Stroke
Vaccination
TitleAssociation between COVID-19 vaccination and stroke: a nationwide case-control study in Qatar
TypeArticle
Volume Number145
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record