Show simple item record

AuthorBugazia, Doaa
AuthorAl-Najjar, Ebtesam
AuthorEsmail, Abdullah
AuthorAbdelrahim, Saifudeen
AuthorAbboud, Karen
AuthorAbdelrahim, Adham
AuthorUmoru, Godsfavour
AuthorRayyan, Hashem A.
AuthorAbudayyeh, Ala
AuthorAl Moustafa, Ala Eddin
AuthorAbdelrahim, Maen
Available date2024-11-03T08:14:55Z
Publication Date2024-07-01
Publication NameFrontiers in Oncology
Identifierhttp://dx.doi.org/10.3389/fonc.2024.1386699
CitationBugazia, D., Al-Najjar, E., Esmail, A., Abdelrahim, S., Abboud, K., Abdelrahim, A., ... & Abdelrahim, M. (2024). Pancreatic ductal adenocarcinoma: the latest on diagnosis, molecular profiling, and systemic treatments. Frontiers in Oncology, 14.
ISSN2234-943X
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85198529184&origin=inward
URIhttp://hdl.handle.net/10576/60798
AbstractPancreatic ductal adenocarcinoma (PDAC) is currently the fourth leading cause of death in the United States and is expected to be ranked second in the next 10 years due to poor prognosis and a rising incidence. Distant metastatic PDAC is associated with the worst prognosis among the different phases of PDAC. The diagnostic options for PDAC are convenient and available for staging, tumor response evaluation, and management of resectable or borderline resectable PDAC. However, imaging is crucial in PDAC diagnosis, monitoring, resectability appraisal, and response evaluation. The advancement of medical technologies is evolving, hence the use of imaging in PDAC treatment options has grown as well as the utilization of ctDNA as a tumor marker. Treatment options for metastatic PDAC are minimal with the primary goal of therapy limited to symptom relief or palliation, especially in patients with low functional capacity at the point of diagnosis. Molecular profiling has shown promising potential solutions that would push the treatment boundaries for patients with PDAC. In this review, we will discuss the latest updates from evidence-based guidelines regarding diagnosis, therapy response evaluation, prognosis, and surveillance, as well as illustrating novel therapies that have been recently investigated for PDAC, in addition to discussing the molecular profiling advances in PDAC.
Languageen
PublisherFrontiers Media S.A.
Subjectcomputed tomography (CT)
magnetic resonance imaging (MRI)
molecular profiling
pancreatic cancer novel therapy
pancreatic cancer treatments
pancreatic ductal adenocarcinoma
pancreatic neoplasm
TitlePancreatic ductal adenocarcinoma: the latest on diagnosis, molecular profiling, and systemic treatments
TypeArticle
Volume Number14
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record