Interaction of High- and Low-Risk Human Papillomavirus Genotypes is Associated with a Reduced Risk of Developing Cervical Cancer.
Date
2024-09-20Author
Hasanzadeh, MaliheRejali, Marzieh
Khalili-Tanha, Ghazaleh
Mehramiz, Mehraneh
Yavari, Negar
Nazari, Elham
Malakuti, Parnian
Maleki, Faezeh
Ghorbannezhad, Ghazale
Rafiei, Mahdi
Mirani, Anahita
Gholampoor-Shamkani, Negar
Saber, Hoda
Mousavi Seresht, Leila
Emamdadi-Aliabad, Zohreh
Mahdian, Zahra
Akbari, Mahdieh
Ferns, Gordon A
Al Moustafa, Ala-Eddin
Avan, Amir
...show more authors ...show less authors
Metadata
Show full item recordAbstract
Cervical cancer is among the most common types of cancer in women and is associated with human papillomavirus (HPV) infection. The association between cervical cancer and high-risk HPV infection has been well documented. However, the effect of simultaneous infection with high- and low-risk HPV or low-risk HPV alone on the risk of developing cervical malignancy remains unanswered in guidelines. We investigated the association of high and low-risk HPVs (HR or LR) genotypes with cervical carcinoma risk and pathological and cytological information in cases recruited from a population-based cohort study of 790 patients. Correlation matrix and t-test were used for analysis. The percentage of HR+LR and HR-HPV16/18 were 9.30% and 11.20% in class II, 7.15% and 7.10% in class IV, and 7.15% and 5.80% in As-CUS smears. Interestingly, concurrent infection with HR-HPV and LR-HPV types led to a significant reduction in the risk of developing malignancy compared to the high-risk group (OR=0.3 (0.098-0.925), pvalue=0.04). The percentage of individuals with cervical malignancy was 10.2% and 28.2% within the co-infected and the HR-HPV participants. Our findings suggest that simultaneous infection with high- and low-risk HPV may reduce the risk of cervical malignancy.
DOI/handle
http://hdl.handle.net/10576/61084Collections
- Medicine Research [1519 items ]