Browsing Biomedical Research Center by Author "Abou-Saleh, Haissam"
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Assessment of the Neutralizing Antibody Response of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Naïve and Previously Infected Individuals: A Comparative Study
Shurrab, Farah M.; Al-Sadeq, Duaa W.; Abou-Saleh, Haissam; Al-Dewik, Nader; Elsharafi, Amira E.; Hamaydeh, Fatima M.; Abo Halawa, Bushra Y.; Jamaleddin, Tala M.; Abdul Hameed, Huda M.; Nizamuddin, Parveen B.; Amanullah, Fathima Humaira; Daas, Hanin I.; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2022 , Report)The currently authorized mRNA COVID-19 vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, offer great promise for reducing the spread of the COVID-19 by generating protective immunity against SARS-CoV-2. Recently, it was ... -
Evaluation of Metal-Organic Framework MIL-89 Nanoparticles Toxicity on Embryonic Zebrafish Development
Dana E., Al-Ansari; Al-Badr, Mashael; Zakaria, Zain Z.; Mohamed, Nura Adam; Nasrallah, Gheyath K.; Yalcin, Huseyin C.; Abou-Saleh, Haissam... more authors ... less authors ( Elsevier , 2022 , Article)Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still ... -
Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months
Salma, Younes; Nicolai, Eleonora; Al-Sadeq, Duaa W.; Younes, Nadin; Al-Dewik, Nader; Abou-Saleh, Haissam; Abo-Halawa, Bushra Y.; Eid, Ali Hussein; Pieri, Massimo; Liu, Na; Daas, Hanin I.; Yassine, Hadi M.; Nizamuddin, Parveen B.; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( Elsevier , 2023 , Article)BackgroundEvidence on the effectiveness of vaccination-induced immunity compared to SARS-CoV-2 natural immunity is warranted to inform vaccination recommendations. AimIn this study, we aimed to conduct a comparative ... -
Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model
Abou-Saleh, Haissam; Younes, Nadin; Rasool, Kashif; Younis, Manaf H.; Prieto, Rafael M.; Yassine, Hadi M.; Mahmoud, Khaled A.; Pintus, Gianfranco; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2019 , Article)The use of chitosan nanoparticles (ChNPs) in various biological and environmental applications is attracting great interest. However, potential side effects related to ChNP toxicity remain the major limitation hampering ... -
Internalization of metal-organic framework nanoparticles in human vascular cells: Implications for cardiovascular disease therapy
Al-Ansari, Dana E.; Mohamed, Nura A.; Marei, Isra; Zekri, Atef; Kameno, Yu; Davies, Robert P.; Lickiss, Paul D.; Rahman, Md Mizanur; Abou-Saleh, Haissam... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The ... -
Novel CD44-downstream signaling pathways mediating breast tumor invasion
Ouhtit, Allal; Rizeq, Balsam; Abou Saleh, Haissam; Rahman, MD Mizanur; Zayed, Hatem ( Ivyspring International Publisher , 2018 , Article Review)CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including ... -
Studies on metal–organic framework (MOF) nanomedicine preparations of sildenafil for the future treatment of pulmonary arterial hypertension
Mohamed, Nura A.; Abou-Saleh, Haissam; Kameno, Yu; Marei, Isra; de Nucci, Gilberto; Ahmetaj-Shala, Blerina; Shala, Fisnik; Kirkby, Nicholas S.; Jennings, Lewis; Al-Ansari, Dana E.; Davies, Robert P.; Lickiss, Paul D.; Mitchell, Jane A.... more authors ... less authors ( nature , 2021 , Article)Pulmonary arterial hypertension (PAH) is an incurable disease, although symptoms are treated with a range of dilator drugs. Despite their clinical benefits, these drugs are limited by systemic side-effects. It is, therefore, ... -
Validation of a Novel Fluorescent Lateral Flow Assay for Rapid Qualitative and Quantitative Assessment of Total Anti-SARS-CoV-2 S-RBD Binding Antibody Units (BAU) from Plasma or Fingerstick Whole-Blood of COVID-19 Vaccinees
Younes, Nadin; Al-Sadeq, Duaa W.; Shurrab, Farah M.; Zedan, Hadeel T.; Abou-Saleh, Haissam; Abo-Halawa, Bushra Y.; AlHamaydeh, Fatima M.; Elsharafi, Amira E.; Daas, Hanin I.; Thomas, Swapna; Aboalmaaly, Sahar; Al Farsi, Afra; Al-Buainain, Reeham; Ataelmannan, Samar; Paul, Jiji; Al Saadi, Amana Salih; Yassine, Hadi M.; Majdalawieh, Amin F.; Ismail, Ahmed; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2022 , Article)Background: Limited commercial LFA assays are available to provide a reliable quantitative measurement of the total binding antibody units (BAU/mL) against the receptor-binding domain of the SARS-CoV-2 spike protein (S-RBD). ...