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    Assessment of the Neutralizing Antibody Response of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Naïve and Previously Infected Individuals: A Comparative Study

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    Date
    2022-02-01
    Author
    Shurrab, Farah M.
    Al-Sadeq, Duaa W.
    Abou-Saleh, Haissam
    Al-Dewik, Nader
    Elsharafi, Amira E.
    Hamaydeh, Fatima M.
    Abo Halawa, Bushra Y.
    Jamaleddin, Tala M.
    Abdul Hameed, Huda M.
    Nizamuddin, Parveen B.
    Amanullah, Fathima Humaira
    Daas, Hanin I.
    Abu-Raddad, Laith J.
    Nasrallah, Gheyath K.
    ...show more authors ...show less authors
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    Abstract
    The currently authorized mRNA COVID-19 vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, offer great promise for reducing the spread of the COVID-19 by generating protective immunity against SARS-CoV-2. Recently, it was shown that the magnitude of the neutralizing antibody (NAbs) response correlates with the degree of protection. However, the difference between the immune response in naïve mRNA-vaccinated and previously infected (PI) individuals is not well studied. We investigated the level of NAbs in naïve and PI individuals after 1 to 26 (median = 6) weeks of the second dose of BNT162b2 or mRNA-1273 vaccination. The naïve mRNA-1273 vaccinated group (n = 68) generated significantly higher (~2-fold, p ≤ 0.001) NAbs than the naïve BNT162b2 (n = 358) group. The P -vaccinated group (n = 42) generated significantly higher (~3-fold; p ≤ 0.001) NAbs levels than the naïve-BNT162b2 (n = 426). Additionally, the older age groups produced a significantly higher levels of antibodies than the young age group (>30) (p = 0.0007). Our results showed that mRNA-1273 generated a higher NAbs response than the BNT162b2 vaccine, and the PI group generated the highest level of NAbs response regardless of the type of vaccine.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85124042840&origin=inward
    DOI/handle
    http://dx.doi.org/10.3390/vaccines10020191
    http://hdl.handle.net/10576/30830
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