Browsing Biomedical Research Center by Title
Now showing items 566-585 of 736
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Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation
( Nature Publishing Group , 2016 , Article)Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B ... -
Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model.
( MDPI , 2022 , Article)Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ... -
Reduced vasorin enhances angiotensin II signaling within the aging arterial wall
( Impact Journals , 2018 , Article)The glycosylated protein vasorin physically interacts with the transforming growth factor-beta1 (TGF-β1) and functionally attenuates its fibrogenic signaling in the vascular smooth muscle cells (VSMCs) of the arterial wall. ... -
Reference ranges of lymphocyte subsets in healthy Qatari adults
( Future Medicine Ltd , 2015 , Article)Aim: Determine reference ranges of lymphocyte subsets in healthy Qatari adults. Patients & Methods: Blood samples (n = 150) were investigated using four colors flow cytometery. Results: The mean percentage and absolute ... -
Regular, Intense Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere Shortening and Adverse DNA Methylation Changes Over a Lifetime.
( Frontiers Media , 2021 , Article)Exercise training is one of the few therapeutic interventions that improves health span by delaying the onset of age-related diseases and preventing early death. The length of telomeres, the 5'-TTAGGG -3' tandem repeats ... -
Reinfections in COVID-19 Patients: Impact of Virus Genetic Variability and Host Immunity
( MDPI , 2021 , Article)The COVID-19 pandemic is still posing a devastating threat to social life and economics. Despite the modest decrease in the number of cases during September-November 2020, the number of active cases is on the rise again. ... -
The Relationship between Changes in MYBPC3 Single-Nucleotide Polymorphism-Associated Metabolites and Elite Athletes’ Adaptive Cardiac Function
( MDPI , 2023 , Article Review)Athletic performance is a multifactorial trait influenced by a complex interaction of environmental and genetic factors. Over the last decades, understanding and improving elite athletes’ endurance and performance has ... -
Relative infectiousness of SARS-CoV-2 vaccine breakthrough infections, reinfections, and primary infections.
( Springer , 2022 , Article)SARS-CoV-2 breakthrough infections in vaccinated individuals and in those who had a prior infection have been observed globally, but the transmission potential of these infections is unknown. The RT-qPCR cycle threshold ... -
Reporting of RT-PCR cycle threshold (Ct) values during the first wave of COVID-19 in Qatar improved result interpretation in clinical and public health settings
( Microbiology Society , 2022 , Article)Introduction. The cycle threshold (Ct) value in real-time PCR (RT-PCR) is where a target-specific amplification signal becomes detectable and can infer viral load, risk of transmission and recovery. Use of Ct values in ... -
Repurposing Ivermectin for COVID-19: Molecular Aspects and Therapeutic Possibilities
( Frontiers Media , 2021 , Article)As of January 2021, SARS-CoV-2 has killed over 2 million individuals across the world. As such, there is an urgent need for vaccines and therapeutics to reduce the burden of COVID-19. Several vaccines, including mRNA, ... -
Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)
( MDPI , 2020 , Article)Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. ... -
Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications.
( Bentham Science Publisher , 2022 , Article Review)Neurodegenerative disorders include neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The ... -
Retail Chicken Carcasses as a Reservoir of Multidrug-Resistant .
( Mary Ann Liebert , 2022 , Article)is a major cause of foodborne disease outbreaks worldwide, mainly through poultry. Recently, there has been an increase in multidrug-resistant (MDR) infections globally. The increased drug resistance results in increased ... -
The retrospective study of the metabolic patterns of BCG-vaccination in type-2 diabetic individuals in COVID-19 infection
( Frontiers Media , 2023 , Article)Background: The cross-protective nature of Bacillus Calmette-Guerin (BCG) vaccine against SARS-CoV-2 virus was previously suggested, however its effect in COVID-19 patients with type 2 diabetes (T2D) and the underlying ... -
A review of rapid food safety testing: using lateral flow assay platform to detect foodborne pathogens
( Taylor and Francis Group , 2023 , Article Review)The detrimental impact of foodborne pathogens on human health makes food safety a major concern at all levels of production. Conventional methods to detect foodborne pathogens, such as live culture, high-performance liquid ... -
Review of recent research on biomedical applications of electrospun polymer nanofibers for improved wound healing
( Future Medicine , 2016 , Article)Wound dressings play an important role in a patient’s recovery from health problems, as unattended wounds could lead to serious complications such as infections or, ultimately, even death. Therefore, wound dressings since ... -
A review of smart sensors coupled with Internet of Things and Artificial Intelligence approach for heart failure monitoring
( Springer Nature , 2021 , Article)Over the last decade, there has been a huge demand for health care technologies such as sensors-based prediction using digital health. With the continuous rise in the human population, these technologies showed to be ... -
Review on the visible light photocatalysis for the decomposition of ciprofloxacin, norfloxacin, tetracyclines, and sulfonamides antibiotics in wastewater
( MDPI , 2021 , Article Review)Antibiotics are chemical compounds that are used to kill or prevent bacterial growth. They are used in different fields, such as the medical field, agriculture, and veterinary. Antibiotics end up in wastewater, which causes ... -
Risk Management Assessments and Recommendations Among Students, Staffs, and Health Care Workers in Educational Biomedical Laboratories.
(2021 , Article)Safety in laboratories is one of the most crucial topics for all educational institutes. All-hazards need to be identified, evaluated, and controlled whenever possible, following the risk management (RM) process. This study ... -
Rodent-borne parasites in Qatar: A possible risk at the human-animal-ecosystem interface
( Elsevier , 2024 , Article)Rodents are known reservoirs for a diverse group of zoonotic pathogens that can pose a threat to human health. Therefore, it is crucial to investigate these pathogens to institute prevention and control measures. To achieve ...