تصفح Biomedical Research Center حسب العنوان
السجلات المعروضة 759 -- 778 من 808
-
Ubiquitin-Related Modifier 1 (URM-1) Modulates Cx43 in Breast Cancer Cell Lines.
( MDPI , 2023 , Article)Gap-junction-forming connexins are exquisitely regulated by post-translational modifications (PTMs). In particular, the PTM of connexin 43 (Cx43), a tumor suppressor protein, regulates its turnover and activity. Here, we ... -
Ultrasound controlled paclitaxel releasing system—A novel method for improving the availability of coronary artery drug coated balloon
( Wiley , 2020 , Article)Objectives: The aim of this study is to improve local-drug delivery efficiency and tissue absorption using the ultrasound (US)-responsible drug coating based on a newly developed US-controlled paclitaxel release balloon. ... -
Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system
( Springer , 2021 , Article)Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic cardiomyopathy (DCM), which could be an autonomous disease independent of ... -
Understanding Heritable Variation Among Hosts in Infectious Diseases Through the Lens of Twin Studies
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article Review)Genetic factors have been hypothesized to contribute to the heterogeneity in the response to infectious diseases (IDs). The classical twin design provides a powerful tool to estimate the role of genetic contributions to ... -
Understanding the genetics of early onset obesity in a cohort of children from Qatar.
( Oxford University Press , 2023 , Article)Monogenic obesity is a rare form of obesity due to pathogenic variants in genes implicated in the leptin-melanocortin signaling pathway and accounts for around 5% of severe early onset obesity. Mutations in the genes ... -
Unraveling the proteomic signatures of coronary artery disease and hypercholesterolemia.
( The Association of Basic Medical Sciences , 2024 , Article)Atherosclerosis, a leading cause of coronary artery disease (CAD), is heavily influenced by hypercholesterolemia (HC). Proteomics research has shown promise in identifying biological markers for CAD diagnosis and prognosis. ... -
Unveiling a Biomarker Signature of Meningioma: the Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis
( MDPI , 2023 , Unpublished Work)Meningiomas are the most prevalent primary intracranial tumors. The majority are benign but can undergo dedifferentiation in grades classified from I to III. Meningiomas tremendous variability in tumor behavior and slow ... -
Unveiling a Biomarker Signature of Meningioma: The Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis
( MDPI , 2023 , Article Review)Meningiomas are the most prevalent primary intracranial tumors. The majority are benign but can undergo dedifferentiation into advanced grades classified by World Health Organization (WHO) into Grades 1 to 3. Meningiomas’ ... -
Unveiling GATA3 Signaling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic Potential
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)GATA binding protein 3 (GATA3), a member of the GATA family transcription factors, is a key player in various physiological and pathological conditions. It is known for its ability to bind to the DNA sequence "GATA", which ... -
Urine tests for diagnosis of infectious diseases and antibiotic –resistant pathogens
( IntechOpen , 2019 , Book chapter)The relation between disease and urine was recognized by physicians since the earliest civilization BC. Urine is considered an ideal diagnostic specimen for its noninvasive and easy method of collection. Urinalysis encompasses ... -
Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors
( Springer , 2023 , Article Review)Sodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering ... -
Use of Hemagglutinin Stem Probes Demonstrate Prevalence of Broadly Reactive Group 1 Influenza Antibodies in Human Sera.
( Nature Publishing Group , 2018 , Article)A better understanding of the seroprevalence and specificity of influenza HA stem-directed broadly neutralizing antibodies (bNAbs) in the human population could significantly inform influenza vaccine design efforts. Here, ... -
Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
( Hindawi Publishing Corporation , 2018 , Article)Over the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor cardiovascular research.Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish ... -
Utilization of Complementary Medicine Among Type 2 Diabetes Patients in Qatar: A Cross Sectional Study
( Elsevier , 2025 , Article)BackgroundDiabetes Mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels due to inadequate insulin production or ineffective insulin utilization. The prevalence of DM is rising globally, ... -
Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar
( Springer Nature , 2023 , Article)Background: We characterized and identified the genetic and antigenic variations of circulating rotavirus strains in comparison to used rotavirus vaccines. Methods: Rotavirus-positive samples (n = 231) were collected and ... -
Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses
( Elsevier Inc. , 2016 , Article)Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin ... -
Validation of a Novel Fluorescent Lateral Flow Assay for Rapid Qualitative and Quantitative Assessment of Total Anti-SARS-CoV-2 S-RBD Binding Antibody Units (BAU) from Plasma or Fingerstick Whole-Blood of COVID-19 Vaccinees
( MDPI , 2022 , Article)Background: Limited commercial LFA assays are available to provide a reliable quantitative measurement of the total binding antibody units (BAU/mL) against the receptor-binding domain of the SARS-CoV-2 spike protein (S-RBD). ... -
Variations in respiratory syncytial virus activity following the relaxation of COVID-19 restrictions in Qatar.
( Oxford University Press , 2022 , Article)Despite the relaxation of COVID-19 restrictions in Qatar in October-December 2020, the detection of RSV was reduced ∼25-fold compared with 2019. This dramatic decrease during the typical RSV season could be related to ... -
VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy in recurrent glioblastoma.
( BioMed Central , 2018 , Article)Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma (GB) to anti-angiogenetic treatment with bevacizumab. We hypothesized ... -
Viral meningitis : an overview
( Springer-Verlag , 2021 , Article)Meningitis is a serious condition that affects the central nervous system. It is an inflammation of the meninges, which is the membrane that surrounds both the brain and the spinal cord. Meningitis can be caused by bacterial, ...
