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A YEAST TWO-HYBRID SCREEN REVEALS A STRONG INTERACTION BETWEEN THE LEGIONELLA CHAPERONIN Hsp60 AND THE HOST CELL SMALL HEAT SHOCK PROTEIN Hsp10
(
Akadémiai Kiadó
, 2015 , Article)
L. pneumophila is an intracellular bacterium that replicates inside a membrane-
bound vacuole called Legionella-containing vacuole (LCV), where it plentifully
liberates its HtpB chaperonin. From LCV, HtpB reaches the ...
Long-term in vivo study of biodegradable Zn-Cu stent: A 2-year implantation evaluation in porcine coronary artery
(
Acta Materialia Inc
, 2019 , Article)
In the present study, a novel biodegradable Zn-0.8Cu coronary artery stent was fabricated and implanted into porcine coronary arteries for up to 24 months. Micro-CT analysis showed that the implanted stent was able to ...
Qatar Biobank: A Paradigm of Translating Biobank Science into Evidence-Based Health Care Interventions
(
Mary Ann Liebert
, 2019 , Article)
Biobank science is progressively becoming indispensable for the development of novel diagnostic tools in health care, by pairing standardized high-quality biological samples, phenotypic, and omics data required to best ...
Conception, Implementation, and Integration of Heterogenous Information Technology Infrastructures in the Qatar Biobank
(
Mary Ann Liebert
, 2019 , Article)
The overall goal of the Qatar Biobank (QBB) is to collect, manage, and distribute high-quality human biospecimens with appropriate clinical and/or research annotation and associated phenotypic data, aiming to be an important ...
Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization
(
Elsevier
, 2020 , Article)
Slurry-based Letrozole (LTZ)-loaded proniosomes were designed using sucrose or sorbitol as carriers and various ratios of cholesterol (CH) and Tween 80 (T80) as lipid composition. Proniosomes were hydrated and probe-sonicated ...
Identification and mapping of brain natriuretic peptide in the normal ventricular myocardium of a desert-dwelling mammalian model, the camel (Camelus dromedarius): Immunohistochemical and ultrastructural study
(
Wiley-Liss Inc.
, 2019 , Article)
Brain natriuretic peptide (BNP) is mainly produced in the ventricular myocardium, where it is released into the circulation, producing rapid volume decrease by diuresis, natriuresis, and water shift into the extracellular ...
Flavonoids in hypertension: a brief review of the underlying mechanisms.
(
Elsevier
, 2019 , Article)
Flavonoids are a diverse group of bioactive polyphenolic compounds abundant in dietary plants and herbs. Regular consumption of flavonoids exerts cardio-vasculoprotective effects and may reduce the onset or progression of ...
Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction
(
Portland Press Ltd
, 2018 , Article)
The most common inherited cardiac disorder, hypertrophic cardiomyopathy (HCM), is characterized by thickening of heart muscle, for which genetic mutations in cardiac myosin-binding protein C3 (c-MYBPC3) gene, is the leading ...
Metabolomics and doping analysis: promises and pitfalls.
(
Future Science
, 2020 , Article)
This brief commentary presents an overview of the potential utility of metabolomics-based approaches in doping
analysis, with particular emphasis on areas where the current analytical procedures would most benefit from ...
Recent perspective on CAR and Fcγ-CR T cell immunotherapy for cancers: Preclinical evidence versus clinical outcomes.
(
Elsevier
, 2019 , Article)
The chimeric antigen receptor Tcell (CAR-T cell) immunotherapy currently represents a hot research trend and it is expected to revolutionize the field of cancer therapy. Promising outcomes have been achieved using CAR-T ...