Biomedical Research Center: Recent submissions
Now showing items 81-100 of 771
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Rapid Visual Detection of Methicillin-Resistant Staphylococcus aureus in Human Clinical Samples via Closed LAMP Assay Targeting mecA and spa Genes
( MDPI , 2024 , Article)The emergence of antimicrobial resistance (AMR), particularly methicillin-resistant Staphylococcus aureus (MRSA), poses a significant global health threat as these bacteria increasingly become resistant to the most available ... -
Novel Theileria sp. as an Etiology of Cutaneous Theileriosis among the Vulnerable Arabian Oryx
( MDPI , 2024 , Article)The Arabian Peninsula’s endemic ungulate, Oryx leucoryx, was on the verge of extinction at the end of the 1970s. Despite the different reintroduction programs, the International Union for Conservation of Nature is still ... -
In silico-designed antimicrobial peptide targeting MRSA and E. coli with antibacterial and antibiofilm actions
( Springer Nature , 2024 , Article)Antibiotic resistance is a paramount global health issue, with numerous bacterial strains continually fortifying their resistance against diverse antibiotics. This surge in resistance levels primarily stems from the overuse ... -
Whole genome-based genetic insights of bla NDM producing clinical E. coli isolates in hospital settings of Pakistant
( American Society for Microbiology , 2023 , Article)Carbapenem resistance among Enterobacterales has become a global health concern. Clinical Escherichia coli isolates producing the metallo β-lactamase NDM have been isolated from two hospitals in Faisalabad, Pakistan. These ... -
Medicinal properties of Qatari wetland plants: A review
( AkiNik Publications , 2024 , Article)For over 60,000 years, human dependence on herbal remedies has been a cornerstone of traditional medicine. However, recent times have witnessed escalating concerns about the sustainability of these practices, especially ... -
Wastewater-based epidemiology for tracking bacterial diversity and antibiotic resistance in COVID-19 isolation hospitals in Qatar
( Elsevier , 2023 , Article)BackgroundHospitals are hotspots for antimicrobial resistance genes (ARGs), and play a significant role in their emergence and spread. Large numbers of ARGs will be ejected from hospitals via wastewater systems. Wastewater-based ... -
Antibacterial and catalytic performance of rGO-CNT-ZrO2 composite
( Taylor and Francis Group , 2023 , Article)In recent years, there has been a rise in public awareness regarding antibacterial properties and commercial opportunities for their use in the medical field. The current study describes the fabrication of a ternary ... -
Granulomatous Mastitis With Breast Abscess Caused by Salmonella.
( Springer , 2023 , Report)Granulomatous mastitis (GM) is a rare disease that occurs in young premenopausal women, is mostly idiopathic, and is less likely to be caused by infection and trauma. It is also strongly associated with pregnancy, lactation, ... -
Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential
( Elsevier , 2024 , Article)Plasticizers are considered as newly emerged contaminants. They are added to plastics to increase their flexibility and softness. Phthalate plasticizers including the Di-2-ethylhexyl phthalates (DEHP) are toxic and induce ... -
Efficacy of Euphorbia helioscopia in context to a possible connection between antioxidant and antidiabetic activities: a comparative study of different extracts
( Springer Nature , 2021 , Article)Background: Euphorbia helioscopia, conventionally known as sun spurge, has been used as a traditional medicine to treat different diseases owing to its reported antitumor, antiviral and antioxidant activities. Methods: The ... -
Sulpiride Serves, a Substrate for the Gut Microbiome
( International Dose-Response Society , 2021 , Article)In the contemporary research world, the intestinal microbiome is now envisioned as a new body organ. Recently, the gut microbiome represents a new drug target in the gut, since various orthologues of intestinal drug ... -
Detection of paracetamol as substrate of the gut microbiome
( Pakistan Journal of Pharmaceutical Sciences , 2019 , Article)Gut microbiome, a new organ; represent targets to alter pharmacokinetics of orally administered drugs. Recently, in vitro trials endorsed the idea that orally administered drugs interact and some of their quantity may be ... -
Association between antioxidant metabolites and N-terminal fragment brain natriuretic peptides in insulin-resistant individuals.
( Lippincott, Williams & Wilkins , 2024 , Article)Oxidative stress plays a pivotal role in the development of metabolic syndrome, including heart failure and insulin resistance. The N-terminal fragment of brain natriuretic peptide (NT-proBNP) has been associated with ... -
Development of Recombinant PLC-Zeta Protein as a Therapeutic Intervention for the Clinical Treatment of Oocyte Activation Failure
( MDPI , 2024 , Article)The sperm-specific phospholipase C zeta (PLCζ) protein is widely considered as the predominant physiological stimulus for initiating the Ca2+ release responsible for oocyte activation during mammalian fertilization. The ... -
Mechanisms of body fat distribution and gluteal-femoral fat protection against metabolic disorders
( Frontiers Media SA , 2024 , Article Review)Obesity is a major health problem that affects millions of individuals, and it is associated with metabolic diseases including insulin resistance (IR), type 2 diabetes (T2D), and cardiovascular diseases (CVDs). However, ... -
SARS-CoV-2 infection triggers more potent antibody-dependent cellular cytotoxicity (ADCC) responses than mRNA-, vector-, and inactivated virus-based COVID-19 vaccines
( Wiley , 2024 , Article)Neutralizing antibodies (NAbs) are elicited after infection and vaccination and have been well studied. However, their antibody-dependent cellular cytotoxicity (ADCC) functionality is still poorly characterized. Here, we ... -
Leprosy: Comprehensive insights into pathology, immunology, and cutting-edge treatment strategies, integrating nanoparticles and ethnomedicinal plants
( Frontiers Media , 2024 , Article Review)Mycobacterium leprae is the causative agent responsible for the chronic disease known as leprosy. This condition is characterized by dermal involvement, often leading to peripheral nerve damage, sensory-motor loss, and ... -
Effectiveness of two and three doses of COVID-19 mRNA vaccines against infection, symptoms, and severity in the pre-omicron era: A time-dependent gradient
( Elsevier , 2024 , Article)BackgroundVaccines were developed and deployed to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to characterize patterns in the protection provided by the BNT162b2 and ... -
Pathogenic Homocystinuria-Associated T236N Mutation Dramatically Alters the Biochemical Properties of Cystathionine Beta-Synthase Protein
( MDPI , 2024 , Article)Background: Cystathione beta-synthase (CBS) T236N is a novel mutation associated with pyridoxine non-responsiveness, which presents a significant difficulty in the medical treatment of homocystinuria. Reported severe ... -
Follow-Up and Comparative Assessment of SARS-CoV-2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA-1273 Heterologous Booster Vaccination
( Wiley , 2024 , Article)Background: Priming with ChAdOx1 followed by heterologous boosting is considered in several countries. Nevertheless, analyses comparing the immunogenicity of heterologous booster to homologous primary vaccination regimens ...
