Biomedical Research Center: Recent submissions
Now showing items 361-380 of 738
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Editorial: Unconventional Animal Models in Infectious Disease Research
( Frontiers Media , 2021 , Article)Beyond an in vitro setting, the use of a biological system is considered imperious to unravel the enigma of host-pathogen interactions, particularly those eventuating in an infectious disease scenery. In the past two-decades, ... -
The effect of surface-modified gold nanorods on the early stage of embryonic development and angiogenesis: Insight into the molecular pathways
( MDPI , 2021 , Article)Gold nanorods have been implicated in several biomedical applications. Herein, the effect of two surface-modified gold nanorods on the early stages of embryogenesis and angiogenesis was investigated using avian embryos at ... -
Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential
( Elsevier , 2021 , Article)Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level. However, emerging ... -
Bio-vehicles of cytotoxic drugs for delivery to tumor specific targets for cancer precision therapy
( Elsevier , 2021 , Article Review)Abnormal structural and molecular changes in malignant tissues were thoroughly investigated and utilized to target tumor cells, hence rescuing normal healthy tissues and lowering the unwanted side effects as non-specific ... -
High Endurance Elite Athletes Show Age-dependent Lower Levels of Circulating Complements Compared to Low/Moderate Endurance Elite Athletes
( Frontiers Media , 2021 , Article)Introduction: Aerobic exercise activates the complement system in the peripheral blood. However, the effect of age and high intensity endurance training on the levels of circulating complements and sassociated inflammatory ... -
Investigation of the effect of anticoagulant usage in the flow diverter stent treatment of the patient-specific cerebral aneurysm using the Lagrangian coherent structures
( Elsevier , 2021 , Article)Anticoagulants are prescribed to the flow diverter treated patients to diminish the risk of embolism in the arteries. In the present study, digital subtraction angiography images of a 49-year-old female patient with a left ... -
A review of smart sensors coupled with Internet of Things and Artificial Intelligence approach for heart failure monitoring
( Springer Nature , 2021 , Article)Over the last decade, there has been a huge demand for health care technologies such as sensors-based prediction using digital health. With the continuous rise in the human population, these technologies showed to be ... -
SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy
( Elsevier , 2021 , Article)Background Reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been documented, raising public health concerns. SARS-CoV-2 reinfections were assessed in a cohort of antibody-positive persons ... -
mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar
(2021 , Article)The SARS-CoV-2 pandemic continues to be a global health concern. The mRNA-1273 (Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic COVID-19 due to infection with ‘wild-type’ variants in a ... -
Epidemiological impact of prioritising SARS-CoV-2 vaccination by antibody status: Mathematical modelling analyses
( BMJ Publishing Group , 2021 , Article)Background Vaccines against SARS-CoV-2 have been developed, but their availability falls far short of global needs. This study aimed to investigate the impact of prioritising available doses on the basis of recipient ... -
SARS-CoV-2 seroprevalence in the urban population of Qatar: An analysis of antibody testing on a sample of 112,941 individuals
( Elsevier , 2021 , Article)The study objective was to the assess level of detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the urban population of Qatar. Antibody testing was performed on residual blood specimens ... -
SARS-CoV-2 Infection Is at Herd Immunity in the Majority Segment of the Population of Qatar.
( Oxford University Press , 2021 , Article)Qatar experienced a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic that disproportionately affected the craft and manual worker (CMW) population, who comprise 60% of the total population. This study ... -
Comparison of Available Methods for Investigating The in vitro Activity of Colistin Against Different Gram-Negative Bacilli
( Qatar University Press , 2021 , Poster)Background: The surge in the prevalence of multidrug-resistant (MDR) Gram-negative bacterial infections with limited treatment options and the decrease in the development of new antibiotics are challenges that lead to the ... -
Artificial Intelligence in Predicting Heart Failure
( Qatar University Press , 2021 , Poster)Heart Failure is a major chronic disease that is increasing day by day and a great health burden in health care systems world wide. Artificial intelligence (AI) techniques such as machine learning (ML), deep learning (DL), ... -
Evaluation of antiviral activity of Manuka honey against SARS-CoV-2.
( Qatar University Press , 2021 , Poster)Background and aims: In 2020 a global pandemic was declared caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The pandemic is still ongoing and continues to cause considerable mortality and morbidity ... -
Development of Novel Chalcone Analogs as Potential Multi-Targeted Therapies for Castration-Resistant Prostate Cancer
( Qatar University Press , 2021 , Poster)Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of ... -
Influenza Prevalence and Vaccine Efficacy in Diabetic Patients in Qatar
( Qatar University Press , 2021 , Poster)Introduction: Diabetes (DM) is often recognized as ?an independent risk factor for developing severe respiratory tract infections. Influenza infections are associated with higher hospitalization, morbidity and mortality ... -
Antibiotic Resistance and Virulence Gene Patterns Associated with Avian Pathogenic Escherichia coli from Broiler Chickens in Qatar
( Qatar University Press , 2021 , Poster)Introduction: Avian Pathogenic Escherichia coli (APEC) is the contributing agent behind the avian infectious disease colibacillosis, which causes substantial fatalities in poultry industries that significantly impact the ... -
The Combination of Dasatinib and PD L1 inhibitor prevents the progression of epithelial mesenchymal transition and dramatically blocks cell invasion of HER2 positive breast cancer cells
( Qatar University Press , 2021 , Poster)Introduction: Both Dasatinib (DA), a tyrosine kinase inhibitor that is used for targeted cancer therapy, and programmed death-ligand 1 (PD-1/PD-L1) inhibitor that is an immune checkpoint therapy, play a vital role in the ... -
Development and In Vivo Testing of Smart Nanoparticles for Enhanced Anti-Cancer Activity and Reduced Cardiotoxicity Associated with Tyrosine Kinase Inhibitors
( Qatar University Press , 2021 , Poster)Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One TKI ...
