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المؤلفFernandes, Queenie
المؤلفInchakalody, Varghese Philipose
المؤلفBedhiafi, Takwa
المؤلفMestiri, Sarra
المؤلفTaib, Nassiba
المؤلفUddin, Shahab
المؤلفMerhi, Maysaloun
المؤلفDermime, Said
تاريخ الإتاحة2025-01-22T06:54:06Z
تاريخ النشر2024
اسم المنشورLife Sciences
المصدرScopus
المعرّفhttp://dx.doi.org/10.1016/j.lfs.2023.122390
الرقم المعياري الدولي للكتاب243205
معرّف المصادر الموحدhttp://hdl.handle.net/10576/62336
الملخصThe correlation between chronic inflammation and cancer was initially identified in the 19th century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors, and adhesion molecules, which regulate inflammation, are recognized contributors to neoplastic transformation through various mechanisms, including oncogenic mutations, resistance to apoptosis, and adaptive responses like angiogenesis. This review aims to establish connections between the intricate and complex mechanisms of chronic inflammation and cancer. We illuminate implicit signaling mechanisms that drive the association between chronic inflammation and the initiation/progression of cancer, exploring potential impacts on other diseases. Additionally, we discuss the modalities of currently available therapeutic options for chronic inflammation and cancer, emphasizing the dual nature of such therapies. A thorough understanding of the molecular basis of chronic inflammation is crucial for developing novel approaches in the prevention and treatment of cancer.
راعي المشروعThe Open Access funding is provided by Qatar National Library, Doha, Qatar.
اللغةen
الناشرElsevier
الموضوعAnti-inflammatory drugs
Cancer
Cancer therapy
Chronic inflammation
Signaling pathways
العنوانChronic inflammation and cancer; the two sides of a coin
النوعArticle Review
رقم المجلد338
dc.accessType Open Access


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