Browsing Laboratory Animal Research Center by Title
Now showing items 39-58 of 97
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Exploring Dysregulated Signaling Pathways in Cancer.
( Bentham Science Publishers , 2020 , Article Review)Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from the exterior of cell to intracellular ... -
Exploring the natural products chemical space to abrogate the F3L-dsRNA interface of monkeypox virus to enhance the immune responses using molecular screening and free energy calculations
( Frontiers Media SA , 2023 , Article)Amid the ongoing monkeypox outbreak, there is an urgent need for the rapid development of effective therapeutic interventions capable of countering the immune evasion mechanisms employed by the monkeypox virus (MPXV). The ... -
Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK)
(2016 , Poster)Psoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified ... -
Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance.
( Springer Verlag , 2019 , Article)The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of the tumor ... -
F-box proteins in cancer stemness: An emerging prognostic and therapeutic target
( Elsevier , 2021 , Article)Cancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, ... -
Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients
( MDPI , 2023 , Article Review)Atopic dermatitis (AD) is the most common chronic relapsing neuroinflammatory skin disease that is characterized by a complex and multifactorial pathophysiology. It reflects a profound interplay between genetic and ... -
Functional In Vivo Imaging of Tumors.
( Springer , 2020 , Book chapter)Noninvasive imaging of functional and molecular changes in cancer has become an indispensable tool for studying cancer in vivo. Targeting the functional and molecular changes in cancer imaging provides a platform for the ... -
Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder.
( MDPI , 2020 , Article Review)Post-traumatic stress disorder (PTSD) is a highly disabling condition, increasingly recognized as both a disorder of mental health and social burden, but also as an anxiety disorder characterized by fear, stress, and ... -
Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder
( Springer Nature , 2021 , Article Review)Attention-deficit hyperactivity disorder (ADHD) is a neurological and neurodevelopmental childhood-onset disorder characterized by a persistent pattern of inattentiveness, impulsiveness, restlessness, and hyperactivity. ... -
Genetics of glutamate and its receptors in autism spectrum disorder
( Springer Nature , 2022 , Article Review)Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by deficits in social interaction skills, impaired communication, and repetitive and restricted behaviors that are thought to be due to altered ... -
Genetics of structural and functional brain changes in autism spectrum disorder.
( Springer Nature , 2020 , Article Review)Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and communicative behaviors. It may occur as an isolated disorder or in the context ... -
Gut Microbiota and Health: Understanding the Role of Diet
( Scientific Research Publishing , 2019 , Article Review)Microbiome now is considered as an organ within our system to regulate metabolism, cellular immune response and eventually maintain the health. Gut microbiota has been studied extensively in the recent past due to the ... -
Gut Microbiota Dysbiosis and Their Impact on Biochemical and Inflammatory Profiles in Cafeteria Diet Fed Sprague Dawley Rats
( Scientific Research Publishing , 2019 , Article)Gut microbiota plays a major role in regulating the host metabolism and immune system. However, the structure of microbiome population is altered constantly by diverse factors including diet and environment. In particular, ... -
Gut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats
( Scientific Research Publishing , 2018 , Article)Diet plays a major role in the body physiology and metabolism. The quantity, nature and stability of the macronutrients present in the diet have a major impact on the composition of gut microbiota. Gut microbiota plays a ... -
Humane care and use of laboratory animals training program (HCULA)
(2017 , Poster)HCULA is the first basic training program that covers the use of Rodents as animals models in biomedical research, it is composed of theory and hands on training courses . The theory course is required to all students ... -
In silico-designed antimicrobial peptide targeting MRSA and E. coli with antibacterial and antibiofilm actions
( Springer Nature , 2024 , Article)Antibiotic resistance is a paramount global health issue, with numerous bacterial strains continually fortifying their resistance against diverse antibiotics. This surge in resistance levels primarily stems from the overuse ... -
In Vitro Analysis of Psoriasis Linked CARMA2sh Gene in Keratinocytes and Mouse Embryonic Stem Cells towards Developing a Murine Transgenic Model
( American Association For Laboratory Animal Science , 2017 , Poster)Psoriasis is a debilitating skin disease affecting approximately 23% of human population. Genome-wide association studies have identified more than 40 susceptibility loci for psoriasis. CARMA2 proteins play a major role ... -
In Vitro and In Vivo Validation of GATA-3 Suppression for Induction of Adipogenesis and Improving Insulin Sensitivity
( MDPI , 2022 , Article)Impaired adipogenesis is associated with the development of insulin resistance and an increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin ... -
In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway
( Elsevier , 2023 , Article)Background: Cutaneous T cell lymphoma (CTCL) is a T cell-derived non-Hodgkin lymphoma primarily affecting the skin, with treatment posing a significant challenge and low survival rates. Objective: In this study, we ... -
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies
( Frontiers Media , 2021 , Article Review)Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with decreased ...