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    F-box proteins in cancer stemness: An emerging prognostic and therapeutic target

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    1-s2.0-S1359644621003147-main.pdf (1.143Mb)
    Date
    2021-12-31
    Author
    Abdul Q., Khan
    Al-Tamimi, Maha
    Uddin, Shahab
    Steinhoff, Martin
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    Abstract
    Cancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, disease relapse, and therapeutic resistance. Hence, it is imperative to explore how progenitor or cancer-initiating cells acquire stemness features and reprogram different biological mechanisms to maintain their sustained oncogenicity. Interestingly, deregulation of F-box proteins (FBPs) is crucial for cancer stemness features, including drug resistance and disease relapse. In this review, we highlight recent updates on the clinical significance of targeting FBPs in cancer therapy, with emphasis on eliminating CSCs and associated therapeutic challenges. Moreover, we also discuss novel strategies for the selective elimination of CSCs by targeting FBPs.
    URI
    https://www.sciencedirect.com/science/article/pii/S1359644621003147
    DOI/handle
    http://dx.doi.org/10.1016/j.drudis.2021.07.006
    http://hdl.handle.net/10576/37765
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    • Laboratory Animal Research Center (Research) [‎131‎ items ]
    • Medicine Research [‎1794‎ items ]

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