Browsing Laboratory Animal Research Center by Type "Article Review"
Now showing items 1-20 of 48
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Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)The growing global burden of malignant tumors with increasing incidence and mortality rates underscores the urgent need for more effective and less toxic therapeutic options. Herbal compounds are being increasingly studied ... -
Applications of polydopaminic nanomaterials in mucosal drug delivery
( Elsevier , 2023 , Article Review)Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic ... -
Association between maternal exposure to polycyclic aromatic hydrocarbons and birth anthropometric outcomes: A systematic review and meta-analysis
( Elsevier , 2024 , Article Review)BackgroundPrevious research has proposed that exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy could potentially lead to a higher risk of adverse birth anthropometric outcomes. However, the current ... -
Association of genes with phenotype in autism spectrum disorder.
( Impact Journals , 2019 , Article Review)Autism spectrum disorder (ASD) is a genetic heterogeneous neurodevelopmental disorder that is characterized by impairments in social interaction and speech development and is accompanied by stereotypical behaviors such as ... -
Beyond genetics: Exploring the role of epigenetic alterations in breast cancer
( Elsevier , 2024 , Article Review)Breast cancer remains a major global health challenge. Its rising incidence is attributed to factors such as delayed diagnosis, the complexity of its subtypes, and increasing drug resistance, all contributing to less-than-ideal ... -
Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury
( Scientific Research Publishing , 2019 , Article Review)Cadmium is a known environmental pollutant targeting various organs. Often implicated in cadmium toxicology is the formation of reactive oxygen species, overwhelming the free radical scavenging mechanisms and inducing ... -
Cadmium: An Emerging Role in Adipose Tissue Dysfunction
( Springer , 2021 , Article Review)Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd adversely affects human health and ... -
Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
( Springer , 2024 , Article Review)Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to ... -
Cardiovascular challenges in the era of antiretroviral therapy for AIDS/ HIV: A comprehensive review of research advancements, pathophysiological insights, and future directions
( Elsevier , 2024 , Article Review)Cardiovascular disease, particularly coronary heart disease, is becoming more common among those living with HIV. Individuals with HIV face an increased susceptibility to myocardial infarction, also known as a heart attack, ... -
Cardiovascular diseases crossroads: cGAS-STING signaling and disease progression
( Elsevier , 2024 , Article Review)It is now widely accepted that inflammation is critical in cardiovascular diseases (CVD). Here, studies are being conducted on how cyclic GMP-AMP synthase (cGAS), a component of innate immunity's DNA-sensing machinery, ... -
Chemokine-cytokine networks in the head and neck tumor microenvironment
( MDPI , 2021 , Article Review)Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a dismal patient prognosis. Despite significant advances in treatment modalities, the five-year survival rate in patients with HNSCC has improved ... -
Chronic inflammation and cancer; the two sides of a coin
( Elsevier , 2024 , Article Review)The correlation between chronic inflammation and cancer was initially identified in the 19th century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors, and adhesion molecules, which regulate ... -
Claudin-1, A Double-Edged Sword in Cancer.
( MDPI , 2020 , Article Review)Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated ... -
The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities
( Elsevier , 2024 , Article Review)Mycosis Fungoides (MF) and Sézary Syndrome (SS) belong to a wide spectrum of T cell lymphoproliferative disorders collectively termed cutaneous T cell lymphomas (CTCL). CTCLs represent an archetype of heterogeneous and ... -
Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
( Wiley , 2022 , Article Review)Colorectal cancer (CRC) is a predominant life-threatening cancer, with liver and peritoneal metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor, nurtures a local inflammatory environment ... -
Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
( BMC , 2021 , Article Review)Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account ... -
Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications.
( Elsevier , 2020 , Article Review)The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor ... -
Epigenetic control of inflammation in Atopic Dermatitis
( Elsevier , 2024 , Article Review)Atopic dermatitis (AD), also known as atopic eczema, is a common but also complex chronic, itchy skin condition with underlying inflammation of the skin. This skin ailment is prevalent worldwide and affects people of all ... -
Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions
( Elsevier , 2023 , Article Review)Cancer ‘stemness’ is fundamental to cancer existence. It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a growing tumor also help evade the ... -
Exploring Dysregulated Signaling Pathways in Cancer.
( Bentham Science Publishers , 2020 , Article Review)Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from the exterior of cell to intracellular ...
