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المؤلفKanekiyo, Masaru
المؤلفJoyce, M Gordon
المؤلفGillespie, Rebecca A
المؤلفGallagher, John R
المؤلفAndrews, Sarah F
المؤلفYassine, Hadi M
المؤلفWheatley, Adam K
المؤلفFisher, Brian E
المؤلفAmbrozak, David R
المؤلفCreanga, Adrian
المؤلفLeung, Kwanyee
المؤلفYang, Eun Sung
المؤلفBoyoglu-Barnum, Seyhan
المؤلفGeorgiev, Ivelin S
المؤلفTsybovsky, Yaroslav
المؤلفPrabhakaran, Madhu S
المؤلفAndersen, Hanne
المؤلفKong, Wing-Pui
المؤلفBaxa, Ulrich
المؤلفZephir, Kathryn L
المؤلفLedgerwood, Julie E
المؤلفKoup, Richard A
المؤلفKwong, Peter D
المؤلفHarris, Audray K
المؤلفMcDermott, Adrian B
المؤلفMascola, John R
المؤلفGraham, Barney S
تاريخ الإتاحة2019-03-05T11:19:21Z
تاريخ النشر2019-03-01
اسم المنشورNature Immunology
المعرّفhttp://dx.doi.org/10.1038/s41590-018-0305-x
الاقتباسKanekiyo M, Joyce MG, Gillespie RA, Gallagher JR, Andrews SF, Yassine HM, Wheatley AK, Fisher BE, Ambrozak DR, Creanga A, Leung K, Yang ES, Boyoglu-Barnum S, Georgiev IS, Tsybovsky Y, Prabhakaran MS, Andersen H, Kong WP, Baxa U, Zephir KL, Ledgerwood JE, Koup RA, Kwong PD, Harris AK, McDermott AB, Mascola JR, Graham BS. Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. Nat Immunol. 2019 Mar;20(3):362-372. doi: 10.1038/s41590-018-0305-x.
الرقم المعياري الدولي للكتاب1529-2908
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11373
الملخصThe present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against influenza. Here we designed a vaccine using the hypervariable receptor-binding domain (RBD) of viral hemagglutinin displayed on a nanoparticle (np) able to elicit antibody responses that neutralize H1N1 influenza viruses spanning over 90 years. Co-display of RBDs from multiple strains across time, so that the adjacent RBDs are heterotypic, provides an avidity advantage to cross-reactive B cells. Immunization with the mosaic RBD-np elicited broader antibody responses than those induced by an admixture of nanoparticles encompassing the same set of RBDs as separate homotypic arrays. Furthermore, we identified a broadly neutralizing monoclonal antibody in a mouse immunized with mosaic RBD-np. The mosaic antigen array signifies a unique approach that subverts monotypic immunodominance and allows otherwise subdominant cross-reactive B cell responses to emerge.
اللغةen
الناشرNature Research
الموضوعnanoparticle
influenza virus
العنوانMosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.
النوعArticle
الصفحات362-372
رقم العدد3
رقم المجلد20
ESSN1529-2916
dc.accessType Abstract Only


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