Show simple item record

AuthorAkhtar, Saghir
AuthorVranic, Semir
AuthorCyprian, Farhan Sachal
AuthorAl Moustafa, Ala-Eddin
Available date2019-04-04T08:46:26Z
Publication Date2018-04-20
Publication NameFrontiers in Oncology
Identifierhttp://dx.doi.org/10.3389/fonc.2018.00123
CitationAkhtar S, Vranic S, Cyprian FS and Al Moustafa A-E (2018) Epstein–Barr Virus in Gliomas: Cause, Association, or Artifact? Front. Oncol. 8:123. doi: 10.3389/fonc.2018.00123
IdentifierArticle # 123
URIhttp://hdl.handle.net/10576/11472
AbstractGliomas are the most common malignant brain tumors and account for around 60% of all primary central nervous system cancers. Glioblastoma multiforme (GBM) is a grade IV glioma associated with a poor outcome despite recent advances in chemotherapy. The etiology of gliomas is unknown, but neurotropic viruses including the Epstein-Barr virus (EBV) that is transmitted salivary and genital fluids have been implicated recently. EBV is a member of the gamma herpes simplex family of DNA viruses that is known to cause infectious mononucleosis (glandular fever) and is strongly linked with the oncogenesis of several cancers, including B-cell lymphomas, nasopharyngeal, and gastric carcinomas. The fact that EBV is thought to be the causative agent for primary central nervous system (CNS) lymphomas in immune-deficient patients has led to its investigations in other brain tumors including gliomas. Here, we provide a review of the clinical literature pertaining to EBV in gliomas and discuss the possibilities of this virus being simply associative, causative, or even an experimental artifact. We searched the PubMed/MEDLINE databases using the following key words such as: glioma(s), glioblastoma multiforme, brain tumors/cancers, EBV, and neurotropic viruses. Our literature analysis indicates conflicting results on the presence and role of EBV in gliomas. Further comprehensive studies are needed to fully implicate EBV in gliomagenesis and oncomodulation. Understanding the role of EBV and other oncoviruses in the etiology of gliomas, would likely open up new avenues for the treatment and management of these, often fatal, CNS tumors.
Languageen
PublisherFrontiers Media
SubjectEpstein–Barr virus
brain cancer
glioblastoma multiforme
glioma
oncogenesis
TitleEpstein-Barr Virus in Gliomas: Cause, Association, or Artifact?
TypeArticle Review
Volume Number8
ESSN2234-943X
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record