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AuthorGatalica, Zoran
AuthorFeldman, Rebecca
AuthorVranic, Semir
AuthorSpetzler, David
Available date2019-08-22T11:21:44Z
Publication Date2019-06-18
Publication NamePrecision Medicine in Cancer Therapy
Identifierhttp://dx.doi.org/10.1007/978-3-030-16391-4_4
CitationGatalica Z., Feldman R., Vranić S., Spetzler D. (2019) Immunohistochemistry-Enabled Precision Medicine. In: Von Hoff D., Han H. (eds) Precision Medicine in Cancer Therapy. Cancer Treatment and Research, vol 178. Springer, Cham
IdentifierChapter 4
URIhttp://hdl.handle.net/10576/11704
AbstractImmunohistochemistry (IHC) can be applied to diagnostic aspects of pathologic examination to provide aid in assignment of lineage and histologic type of cancer. Increasingly, however, IHC is widely used to provide prognostic and predictive (theranostic) information about the neoplastic disease. A refinement of theranostic application of IHC can be seen in the use of “genomic probing” where antibody staining results are directly correlated with an underlying genetic alteration in the tumor (somatic mutations) and/or the patient (germline constitution). All these aspects of IHC find their best use in guiding the oncologists in the optimal use of therapy for the patients.
Languageen
PublisherSpringer, Cham
Subjectprecision medicine
biomarkers
pathology
immunohistochemistry
TitleImmunohistochemistry-Enabled Precision Medicine
TypeBook chapter
Pagination111-135
Volume Number178
dc.accessType Abstract Only


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