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المؤلفAlhussain, Hashim
المؤلفAugustine, Robin
المؤلفHussein, Essraa A
المؤلفGupta, Ishita
المؤلفHasan, Anwarul
المؤلفAl Moustafa, Ala-Eddin
المؤلفElzatahry, Ahmed
تاريخ الإتاحة2020-06-24T11:06:11Z
تاريخ النشر2020-03-01
اسم المنشورJournal of Biomedical Nanotechnology
المعرّفhttp://dx.doi.org/10.1166/jbn.2020.2894
الاقتباسAlhussain H, Augustine R, Hussein EA, et al. MXene Nanosheets May Induce Toxic Effect on the Early Stage of Embryogenesis. J Biomed Nanotechnol. 2020;16(3):364-372. doi:10.1166/jbn.2020.2894
الرقم المعياري الدولي للكتاب1550-7033
معرّف المصادر الموحدhttp://hdl.handle.net/10576/15146
الملخصMXene (Ti₃C₂T), as a novel 2D material, has produced a great interest due to its promising properties in biomedical applications, nevertheless, there is a lack of studies dedicated to investigate the possible toxic effect of MXene in embryos. Herein, we aim to scrutinize the potential toxicity of MXene nanosheets on the early stage of the embryo as well as angiogenesis. Avian embryos at 3 and 5 days of incubation were used as an experimental model in this investigation. Our findings reveal that MXene may produce adverse effect on the early stage of embryogenesis as ∼46% of MXene-exposed embryos died during 1-5 days after exposure. We also found that MXene at tested concentration inhibits angiogenesis of the chorioallantoic membrane of the embryo after 5 days of incubation. More significantly, RT-PCR analysis of seven genes, which are key regulators of cell proliferation, survival, cell death and angiogenesis, revealed that these genes were deregulated in brain, heart and liver tissues from MXene-treated embryos in comparison with their matched controls. Our study clearly suggests that MXene at studied concentration might induce a toxic effect on the early stage of embryogenesis; nevertheless, more investigations are necessary to understand the effect at low concentrations and elucidate its mechanism at the early stage of normal development.
راعي المشروعBy Qatar University grants #: QUHI-CMED-19/20-1 and GCC # 2017-002 QU/KU Qatar National Research Fund grant #: NPRP9-144-3-021
اللغةen
الناشرAmerican Scientific Publishers
الموضوعMXene
Ti3C2Tx
Avian Embryo
Angiogenesis
Toxicity
Gene Expression
العنوانMXene Nanosheets May Induce Toxic Effect on the Early Stage of Embryogenesis.
النوعArticle
الصفحات364-372
رقم العدد3
رقم المجلد16
ESSN1550-7041
dc.accessType Abstract Only


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