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AuthorAlhussain, Hashim
AuthorAugustine, Robin
AuthorHussein, Essraa A
AuthorGupta, Ishita
AuthorHasan, Anwarul
AuthorAl Moustafa, Ala-Eddin
AuthorElzatahry, Ahmed
Available date2020-06-24T11:06:11Z
Publication Date2020-03-01
Publication NameJournal of Biomedical Nanotechnology
Identifierhttp://dx.doi.org/10.1166/jbn.2020.2894
CitationAlhussain H, Augustine R, Hussein EA, et al. MXene Nanosheets May Induce Toxic Effect on the Early Stage of Embryogenesis. J Biomed Nanotechnol. 2020;16(3):364-372. doi:10.1166/jbn.2020.2894
ISSN1550-7033
URIhttp://hdl.handle.net/10576/15146
AbstractMXene (Ti₃C₂T), as a novel 2D material, has produced a great interest due to its promising properties in biomedical applications, nevertheless, there is a lack of studies dedicated to investigate the possible toxic effect of MXene in embryos. Herein, we aim to scrutinize the potential toxicity of MXene nanosheets on the early stage of the embryo as well as angiogenesis. Avian embryos at 3 and 5 days of incubation were used as an experimental model in this investigation. Our findings reveal that MXene may produce adverse effect on the early stage of embryogenesis as ∼46% of MXene-exposed embryos died during 1-5 days after exposure. We also found that MXene at tested concentration inhibits angiogenesis of the chorioallantoic membrane of the embryo after 5 days of incubation. More significantly, RT-PCR analysis of seven genes, which are key regulators of cell proliferation, survival, cell death and angiogenesis, revealed that these genes were deregulated in brain, heart and liver tissues from MXene-treated embryos in comparison with their matched controls. Our study clearly suggests that MXene at studied concentration might induce a toxic effect on the early stage of embryogenesis; nevertheless, more investigations are necessary to understand the effect at low concentrations and elucidate its mechanism at the early stage of normal development.
SponsorBy Qatar University grants #: QUHI-CMED-19/20-1 and GCC # 2017-002 QU/KU Qatar National Research Fund grant #: NPRP9-144-3-021
Languageen
PublisherAmerican Scientific Publishers
SubjectMXene
Ti3C2Tx
Avian Embryo
Angiogenesis
Toxicity
Gene Expression
TitleMXene Nanosheets May Induce Toxic Effect on the Early Stage of Embryogenesis.
TypeArticle
Pagination364-372
Issue Number3
Volume Number16
ESSN1550-7041
dc.accessType Abstract Only


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